Deceased-donor kidney transplantation

Improvement in long-term survival

David Serur, Stuart Saal, John Wang, John Sullivan, Roxana Bologa, Choli Hartono, Darshana Dadhania, Jun Lee, Linda M. Gerber, Michael Goldstein, Sandip Kapur, William Stubenbord, Rimma Belenkaya, Marina Marin, Surya Seshan, Quanhong Ni, Daniel Levine, Thomas Parker, Kurt Stenzel, Barry Smith & 2 others Robert Riggio, Jhoong Cheigh

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background. Despite marked improvement in short-term renal allograft survival rates (GSR) in recent years, improvement in long-term GSR remained elusive.Methods. We analysed the kidney transplant experience at our centre accrued over four decades to evaluate how short-term and long-term GSR had changed and to identify risk factors affecting graft survival. The study included 1476 adult recipients of a deceased-donor kidney transplant who were transplanted between 1963 and 2006 and who had received one of five distinct immunosuppressive protocols.Results. Five-year actual GSR steadily improved over the years as immunosuppressive therapy evolved (2286%, P < 0.001) in spite of an increasing trend in the transplantation of higher-risk donorrecipient pairings. For those whose grafts functioned for the first year, subsequent 4-year GSR (5-year conditional GSR) also improved significantly (6392%, P < 0.001). Acute rejection and delayed graft function (DGF) were the most significant risk factors for actual graft survival, while acute rejection was the only significant risk factor for conditional GSR. Use of kidneys from expanded-criteria donors (ECD) was not a risk factor, compared to the use of standard-criteria donor kidneys for either 5-year actual or conditional GSR. There was an impressive decline in the incidence of acute rejection events (77.45.8%, P < 0.001). While the DGF rate had decreased, it still remained high (68.738.5%, P < 0.001).Conclusions. We found a significant improvement in both short-term and long-term GSR of deceased-donor kidney transplants over the last four decades. These improvements are most likely related to the decreased incidence of acute rejection episodes. Minimizing acute rejection events and preventing DGF could result in further improvement in the GSR. Our experience in the judicious use of ECD kidneys suggests that this source of kidneys could be expanded further.

Original languageEnglish (US)
Pages (from-to)317-324
Number of pages8
JournalNephrology Dialysis Transplantation
Volume26
Issue number1
DOIs
StatePublished - Jan 2011
Externally publishedYes

Fingerprint

Kidney Transplantation
Kidney
Delayed Graft Function
Transplants
Graft Survival
Immunosuppressive Agents
Incidence
Allografts
Transplantation

Keywords

  • acute rejection
  • deceased donors
  • delayed graft function
  • immunosuppressive therapy
  • kidney (renal) transplantation

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Serur, D., Saal, S., Wang, J., Sullivan, J., Bologa, R., Hartono, C., ... Cheigh, J. (2011). Deceased-donor kidney transplantation: Improvement in long-term survival. Nephrology Dialysis Transplantation, 26(1), 317-324. https://doi.org/10.1093/ndt/gfq415

Deceased-donor kidney transplantation : Improvement in long-term survival. / Serur, David; Saal, Stuart; Wang, John; Sullivan, John; Bologa, Roxana; Hartono, Choli; Dadhania, Darshana; Lee, Jun; Gerber, Linda M.; Goldstein, Michael; Kapur, Sandip; Stubenbord, William; Belenkaya, Rimma; Marin, Marina; Seshan, Surya; Ni, Quanhong; Levine, Daniel; Parker, Thomas; Stenzel, Kurt; Smith, Barry; Riggio, Robert; Cheigh, Jhoong.

In: Nephrology Dialysis Transplantation, Vol. 26, No. 1, 01.2011, p. 317-324.

Research output: Contribution to journalArticle

Serur, D, Saal, S, Wang, J, Sullivan, J, Bologa, R, Hartono, C, Dadhania, D, Lee, J, Gerber, LM, Goldstein, M, Kapur, S, Stubenbord, W, Belenkaya, R, Marin, M, Seshan, S, Ni, Q, Levine, D, Parker, T, Stenzel, K, Smith, B, Riggio, R & Cheigh, J 2011, 'Deceased-donor kidney transplantation: Improvement in long-term survival', Nephrology Dialysis Transplantation, vol. 26, no. 1, pp. 317-324. https://doi.org/10.1093/ndt/gfq415
Serur, David ; Saal, Stuart ; Wang, John ; Sullivan, John ; Bologa, Roxana ; Hartono, Choli ; Dadhania, Darshana ; Lee, Jun ; Gerber, Linda M. ; Goldstein, Michael ; Kapur, Sandip ; Stubenbord, William ; Belenkaya, Rimma ; Marin, Marina ; Seshan, Surya ; Ni, Quanhong ; Levine, Daniel ; Parker, Thomas ; Stenzel, Kurt ; Smith, Barry ; Riggio, Robert ; Cheigh, Jhoong. / Deceased-donor kidney transplantation : Improvement in long-term survival. In: Nephrology Dialysis Transplantation. 2011 ; Vol. 26, No. 1. pp. 317-324.
@article{7d4607c5218e45b594b5e5abb538dd91,
title = "Deceased-donor kidney transplantation: Improvement in long-term survival",
abstract = "Background. Despite marked improvement in short-term renal allograft survival rates (GSR) in recent years, improvement in long-term GSR remained elusive.Methods. We analysed the kidney transplant experience at our centre accrued over four decades to evaluate how short-term and long-term GSR had changed and to identify risk factors affecting graft survival. The study included 1476 adult recipients of a deceased-donor kidney transplant who were transplanted between 1963 and 2006 and who had received one of five distinct immunosuppressive protocols.Results. Five-year actual GSR steadily improved over the years as immunosuppressive therapy evolved (2286{\%}, P < 0.001) in spite of an increasing trend in the transplantation of higher-risk donorrecipient pairings. For those whose grafts functioned for the first year, subsequent 4-year GSR (5-year conditional GSR) also improved significantly (6392{\%}, P < 0.001). Acute rejection and delayed graft function (DGF) were the most significant risk factors for actual graft survival, while acute rejection was the only significant risk factor for conditional GSR. Use of kidneys from expanded-criteria donors (ECD) was not a risk factor, compared to the use of standard-criteria donor kidneys for either 5-year actual or conditional GSR. There was an impressive decline in the incidence of acute rejection events (77.45.8{\%}, P < 0.001). While the DGF rate had decreased, it still remained high (68.738.5{\%}, P < 0.001).Conclusions. We found a significant improvement in both short-term and long-term GSR of deceased-donor kidney transplants over the last four decades. These improvements are most likely related to the decreased incidence of acute rejection episodes. Minimizing acute rejection events and preventing DGF could result in further improvement in the GSR. Our experience in the judicious use of ECD kidneys suggests that this source of kidneys could be expanded further.",
keywords = "acute rejection, deceased donors, delayed graft function, immunosuppressive therapy, kidney (renal) transplantation",
author = "David Serur and Stuart Saal and John Wang and John Sullivan and Roxana Bologa and Choli Hartono and Darshana Dadhania and Jun Lee and Gerber, {Linda M.} and Michael Goldstein and Sandip Kapur and William Stubenbord and Rimma Belenkaya and Marina Marin and Surya Seshan and Quanhong Ni and Daniel Levine and Thomas Parker and Kurt Stenzel and Barry Smith and Robert Riggio and Jhoong Cheigh",
year = "2011",
month = "1",
doi = "10.1093/ndt/gfq415",
language = "English (US)",
volume = "26",
pages = "317--324",
journal = "Nephrology Dialysis Transplantation",
issn = "0931-0509",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Deceased-donor kidney transplantation

T2 - Improvement in long-term survival

AU - Serur, David

AU - Saal, Stuart

AU - Wang, John

AU - Sullivan, John

AU - Bologa, Roxana

AU - Hartono, Choli

AU - Dadhania, Darshana

AU - Lee, Jun

AU - Gerber, Linda M.

AU - Goldstein, Michael

AU - Kapur, Sandip

AU - Stubenbord, William

AU - Belenkaya, Rimma

AU - Marin, Marina

AU - Seshan, Surya

AU - Ni, Quanhong

AU - Levine, Daniel

AU - Parker, Thomas

AU - Stenzel, Kurt

AU - Smith, Barry

AU - Riggio, Robert

AU - Cheigh, Jhoong

PY - 2011/1

Y1 - 2011/1

N2 - Background. Despite marked improvement in short-term renal allograft survival rates (GSR) in recent years, improvement in long-term GSR remained elusive.Methods. We analysed the kidney transplant experience at our centre accrued over four decades to evaluate how short-term and long-term GSR had changed and to identify risk factors affecting graft survival. The study included 1476 adult recipients of a deceased-donor kidney transplant who were transplanted between 1963 and 2006 and who had received one of five distinct immunosuppressive protocols.Results. Five-year actual GSR steadily improved over the years as immunosuppressive therapy evolved (2286%, P < 0.001) in spite of an increasing trend in the transplantation of higher-risk donorrecipient pairings. For those whose grafts functioned for the first year, subsequent 4-year GSR (5-year conditional GSR) also improved significantly (6392%, P < 0.001). Acute rejection and delayed graft function (DGF) were the most significant risk factors for actual graft survival, while acute rejection was the only significant risk factor for conditional GSR. Use of kidneys from expanded-criteria donors (ECD) was not a risk factor, compared to the use of standard-criteria donor kidneys for either 5-year actual or conditional GSR. There was an impressive decline in the incidence of acute rejection events (77.45.8%, P < 0.001). While the DGF rate had decreased, it still remained high (68.738.5%, P < 0.001).Conclusions. We found a significant improvement in both short-term and long-term GSR of deceased-donor kidney transplants over the last four decades. These improvements are most likely related to the decreased incidence of acute rejection episodes. Minimizing acute rejection events and preventing DGF could result in further improvement in the GSR. Our experience in the judicious use of ECD kidneys suggests that this source of kidneys could be expanded further.

AB - Background. Despite marked improvement in short-term renal allograft survival rates (GSR) in recent years, improvement in long-term GSR remained elusive.Methods. We analysed the kidney transplant experience at our centre accrued over four decades to evaluate how short-term and long-term GSR had changed and to identify risk factors affecting graft survival. The study included 1476 adult recipients of a deceased-donor kidney transplant who were transplanted between 1963 and 2006 and who had received one of five distinct immunosuppressive protocols.Results. Five-year actual GSR steadily improved over the years as immunosuppressive therapy evolved (2286%, P < 0.001) in spite of an increasing trend in the transplantation of higher-risk donorrecipient pairings. For those whose grafts functioned for the first year, subsequent 4-year GSR (5-year conditional GSR) also improved significantly (6392%, P < 0.001). Acute rejection and delayed graft function (DGF) were the most significant risk factors for actual graft survival, while acute rejection was the only significant risk factor for conditional GSR. Use of kidneys from expanded-criteria donors (ECD) was not a risk factor, compared to the use of standard-criteria donor kidneys for either 5-year actual or conditional GSR. There was an impressive decline in the incidence of acute rejection events (77.45.8%, P < 0.001). While the DGF rate had decreased, it still remained high (68.738.5%, P < 0.001).Conclusions. We found a significant improvement in both short-term and long-term GSR of deceased-donor kidney transplants over the last four decades. These improvements are most likely related to the decreased incidence of acute rejection episodes. Minimizing acute rejection events and preventing DGF could result in further improvement in the GSR. Our experience in the judicious use of ECD kidneys suggests that this source of kidneys could be expanded further.

KW - acute rejection

KW - deceased donors

KW - delayed graft function

KW - immunosuppressive therapy

KW - kidney (renal) transplantation

UR - http://www.scopus.com/inward/record.url?scp=78650658746&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650658746&partnerID=8YFLogxK

U2 - 10.1093/ndt/gfq415

DO - 10.1093/ndt/gfq415

M3 - Article

VL - 26

SP - 317

EP - 324

JO - Nephrology Dialysis Transplantation

JF - Nephrology Dialysis Transplantation

SN - 0931-0509

IS - 1

ER -