Dealing with misfolded proteins: Examining the neuroprotective role of molecular chaperones in neurodegeneration

Yousuf O. Ali, Brandon M. Kitay, Rong G Zhai

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Human neurodegenerative diseases arise from a wide array of genetic and environmental factors. Despite the diversity in etiology, many of these diseases are considered "conformational" in nature, characterized by the accumulation of pathological, misfolded proteins. These misfolded proteins can induce cellular stress by overloading the proteolytic machinery, ultimately resulting in the accumulation and deposition of aggregated protein species that are cytotoxic. Misfolded proteins may also form aberrant, non-physiological protein-protein interactions leading to the sequestration of other normal proteins essential for cellular functions. The progression of such disease may therefore be viewed as a failure of normal protein homeostasis, a process that involves a network of molecules regulating the synthesis, folding, translocation and clearance of proteins. Molecular chaperones are highly conserved proteins involved in the folding of nascent proteins, and the repair of proteins that have lost their typical conformations. These functions have therefore made molecular chaperones an active area of investigation within the field of conformational diseases. This review will discuss the role of molecular chaperones in neurodegenerative diseases, highlighting their functional classification, regulation, and therapeutic potential for such diseases.

Original languageEnglish
Pages (from-to)6859-6887
Number of pages29
JournalMolecules
Volume15
Issue number10
DOIs
StatePublished - Oct 1 2010

Fingerprint

Molecular Chaperones
proteins
Proteins
Neurodegenerative diseases
Neurodegenerative Diseases
folding
etiology
Protein Folding
homeostasis
Protein Transport
machinery
clearances
Disease Progression
progressions
Homeostasis
Machinery
Conformations
Repair

Keywords

  • Alzheimer's disease
  • Hsp70
  • Hsp90
  • Parkinson's disease
  • PolyQ disease

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Dealing with misfolded proteins : Examining the neuroprotective role of molecular chaperones in neurodegeneration. / Ali, Yousuf O.; Kitay, Brandon M.; Zhai, Rong G.

In: Molecules, Vol. 15, No. 10, 01.10.2010, p. 6859-6887.

Research output: Contribution to journalArticle

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