De novo ANCA-associated vasculitis occurring 14 years after kidney transplantation.

A. Asif, C. Toral, J. Diego, J. Miller, D. Roth

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Abstract

A cadaveric kidney transplant recipient, with no history of a connective tissue disease, was admitted with malaise, arthralgias, diplopia, mild headache, and a painful left eye. The patient was on maintenance immunosuppression for 14 years with cyclosporine and methylprednisolone. Initial laboratory data indicated an elevated serum creatinine from baseline, 2+ proteinuria, and 50 to 100 red blood cells (RBCs)/high-power field (HPF) in the urine. Renal biopsy was consistent with necrotizing vasculitis involving glomerular capillaries, with crescent formation and an absence of immune complexes. Perinuclear antineutrophil cytoplasmic autoantibodies (P-ANCA) and anti-myeloperoxidase (MPO) were found to be elevated. To the best of our knowledge, this is the first reported case of an ANCA-associated small vessel vasculitis (SVV) developing in a renal transplant recipient without history of connective tissue disease.

Original languageEnglish (US)
Pages (from-to)E10
JournalAmerican journal of kidney diseases : the official journal of the National Kidney Foundation
Volume35
Issue number3
StatePublished - Mar 2000

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ASJC Scopus subject areas

  • Nephrology

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