DDAVP in acquired hemophilia a: Case report and review of the literature

Raja Mudad, William H. Kane

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

One patient with an acquired factor VIII inhibitor is reported in which an acute lower intestinal hemorrhage was successfully managed using Desmopressin (DDAVP). The patient initially had a factor VIII level of 10% with a inhibitor titer of 1.9 Bethesda units. Following administration of DDAVP the factor VIII level rose to 86% and there was a decrease in the number and volume of bloody stools. The inhibitor disappeared following treatment with corticosteroids, however the patient ultimately expired due to complications of ischemic colitis. This case and 21 previously reported cases of acquired hemophilia treated with DDAVP are reviewed. The data support a role for DDAVP in the treatment of non life threatening hemorrhage in patients with acquired hemophilia and low titer factor VIII inhibitors (<5 Bethesda units or factor VIII≧5%).

Original languageEnglish (US)
Pages (from-to)295-299
Number of pages5
JournalAmerican Journal of Hematology
Volume43
Issue number4
DOIs
StatePublished - Aug 1993
Externally publishedYes

Keywords

  • DDAVP
  • acquired hemophilia
  • factor VIII inhibitor

ASJC Scopus subject areas

  • Hematology

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