Daunorubicin impairs 1-beta-D-arabinofuranosylcytosine uptake

O. Dal Pozzo; P. A. Bernabei; L. Lombardini; S. Fenigli; G. D'Ippolito; P. R. Ferrini

doi:10.1159/000238891

Daunorubicin impairs 1-beta-D-arabinofuranosylcytosine uptake

O. Dal Pozzo, P. A. Bernabei, L. Lombardini, S. Fenigli, G. D'Ippolito, P. R. Ferrini

Orthopaedics

Research output: Contribution to journal › Article

Abstract

Daunorubicin (DNR) and 1-β-D-arabinofuranosylcytosine (Ara-C) act in a schedule-dependent fashion on leukemic cells. The present study was undertaken to determine whether the inhibition exerted by DNR on Ara-C cytotoxicity on HL 60 cells could be accounted for by an impairment of its uptake. After 250 ng/ml DNR treatment for 30 min, the time course of Ara-C uptake was measured, up to 128 min of incubation at 37°C and at 4°C, compared with controls. We found that DNR inhibits Ara-C uptake both at 37 and 4°C, mostly acting on passive diffusion.

Original language	English (US)
Pages (from-to)	436-440
Number of pages	5
Journal	Chemotherapy
Volume	37
Issue number	6
DOIs	https://doi.org/10.1159/000238891
State	Published - Jan 1 1991

Keywords

1-β-D-arabinofuranosylcytosine
Daunorubicin
Scheduling-dependent effect Antitumor drugs

ASJC Scopus subject areas

Pharmacology (medical)

Access to Document

10.1159/000238891

Fingerprint Dive into the research topics of 'Daunorubicin impairs 1-beta-D-arabinofuranosylcytosine uptake'. Together they form a unique fingerprint.

Cite this

Dal Pozzo, O., Bernabei, P. A., Lombardini, L., Fenigli, S., D'Ippolito, G., & Ferrini, P. R. (1991). Daunorubicin impairs 1-beta-D-arabinofuranosylcytosine uptake. Chemotherapy, 37(6), 436-440. https://doi.org/10.1159/000238891

@article{96cf1a8c89124c03a76a3d39afb1028d,

title = "Daunorubicin impairs 1-beta-D-arabinofuranosylcytosine uptake",

abstract = "Daunorubicin (DNR) and 1-β-D-arabinofuranosylcytosine (Ara-C) act in a schedule-dependent fashion on leukemic cells. The present study was undertaken to determine whether the inhibition exerted by DNR on Ara-C cytotoxicity on HL 60 cells could be accounted for by an impairment of its uptake. After 250 ng/ml DNR treatment for 30 min, the time course of Ara-C uptake was measured, up to 128 min of incubation at 37°C and at 4°C, compared with controls. We found that DNR inhibits Ara-C uptake both at 37 and 4°C, mostly acting on passive diffusion.",

keywords = "1-β-D-arabinofuranosylcytosine, Daunorubicin, Scheduling-dependent effect Antitumor drugs",

author = "{Dal Pozzo}, O. and Bernabei, {P. A.} and L. Lombardini and S. Fenigli and G. D'Ippolito and Ferrini, {P. R.}",

year = "1991",

month = jan,

day = "1",

doi = "10.1159/000238891",

language = "English (US)",

volume = "37",

pages = "436--440",

journal = "Chemotherapy",

issn = "0009-3157",

publisher = "S. Karger AG",

number = "6",

}

TY - JOUR

T1 - Daunorubicin impairs 1-beta-D-arabinofuranosylcytosine uptake

AU - Dal Pozzo, O.

AU - Bernabei, P. A.

AU - Lombardini, L.

AU - Fenigli, S.

AU - D'Ippolito, G.

AU - Ferrini, P. R.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - Daunorubicin (DNR) and 1-β-D-arabinofuranosylcytosine (Ara-C) act in a schedule-dependent fashion on leukemic cells. The present study was undertaken to determine whether the inhibition exerted by DNR on Ara-C cytotoxicity on HL 60 cells could be accounted for by an impairment of its uptake. After 250 ng/ml DNR treatment for 30 min, the time course of Ara-C uptake was measured, up to 128 min of incubation at 37°C and at 4°C, compared with controls. We found that DNR inhibits Ara-C uptake both at 37 and 4°C, mostly acting on passive diffusion.

AB - Daunorubicin (DNR) and 1-β-D-arabinofuranosylcytosine (Ara-C) act in a schedule-dependent fashion on leukemic cells. The present study was undertaken to determine whether the inhibition exerted by DNR on Ara-C cytotoxicity on HL 60 cells could be accounted for by an impairment of its uptake. After 250 ng/ml DNR treatment for 30 min, the time course of Ara-C uptake was measured, up to 128 min of incubation at 37°C and at 4°C, compared with controls. We found that DNR inhibits Ara-C uptake both at 37 and 4°C, mostly acting on passive diffusion.

KW - 1-β-D-arabinofuranosylcytosine

KW - Daunorubicin

KW - Scheduling-dependent effect Antitumor drugs

UR - http://www.scopus.com/inward/record.url?scp=0026095422&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026095422&partnerID=8YFLogxK

U2 - 10.1159/000238891

DO - 10.1159/000238891

M3 - Article

C2 - 1760943

AN - SCOPUS:0026095422

VL - 37

SP - 436

EP - 440

JO - Chemotherapy

JF - Chemotherapy

SN - 0009-3157

IS - 6

ER -