Daunorubicin impairs 1-beta-D-arabinofuranosylcytosine uptake

O. Dal Pozzo, P. A. Bernabei, L. Lombardini, S. Fenigli, G. D'Ippolito, P. R. Ferrini

Research output: Contribution to journalArticlepeer-review


Daunorubicin (DNR) and 1-β-D-arabinofuranosylcytosine (Ara-C) act in a schedule-dependent fashion on leukemic cells. The present study was undertaken to determine whether the inhibition exerted by DNR on Ara-C cytotoxicity on HL 60 cells could be accounted for by an impairment of its uptake. After 250 ng/ml DNR treatment for 30 min, the time course of Ara-C uptake was measured, up to 128 min of incubation at 37°C and at 4°C, compared with controls. We found that DNR inhibits Ara-C uptake both at 37 and 4°C, mostly acting on passive diffusion.

Original languageEnglish (US)
Pages (from-to)436-440
Number of pages5
Issue number6
StatePublished - 1991


  • 1-β-D-arabinofuranosylcytosine
  • Daunorubicin
  • Scheduling-dependent effect Antitumor drugs

ASJC Scopus subject areas

  • Pharmacology (medical)


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