Daunorubicin impairs 1-beta-D-arabinofuranosylcytosine uptake

O. Dal Pozzo; P. A. Bernabei; L. Lombardini; S. Fenigli; G. D'Ippolito; P. R. Ferrini

doi:10.1159/000238891

Daunorubicin impairs 1-beta-D-arabinofuranosylcytosine uptake

O. Dal Pozzo, P. A. Bernabei, L. Lombardini, S. Fenigli, G. D'Ippolito, P. R. Ferrini

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Abstract

Daunorubicin (DNR) and 1-β-D-arabinofuranosylcytosine (Ara-C) act in a schedule-dependent fashion on leukemic cells. The present study was undertaken to determine whether the inhibition exerted by DNR on Ara-C cytotoxicity on HL 60 cells could be accounted for by an impairment of its uptake. After 250 ng/ml DNR treatment for 30 min, the time course of Ara-C uptake was measured, up to 128 min of incubation at 37°C and at 4°C, compared with controls. We found that DNR inhibits Ara-C uptake both at 37 and 4°C, mostly acting on passive diffusion.

Original language	English (US)
Pages (from-to)	436-440
Number of pages	5
Journal	Chemotherapy
Volume	37
Issue number	6
DOIs	https://doi.org/10.1159/000238891
State	Published - 1991

Keywords

1-β-D-arabinofuranosylcytosine
Daunorubicin
Scheduling-dependent effect Antitumor drugs

ASJC Scopus subject areas

Pharmacology (medical)

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10.1159/000238891

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title = "Daunorubicin impairs 1-beta-D-arabinofuranosylcytosine uptake",

abstract = "Daunorubicin (DNR) and 1-β-D-arabinofuranosylcytosine (Ara-C) act in a schedule-dependent fashion on leukemic cells. The present study was undertaken to determine whether the inhibition exerted by DNR on Ara-C cytotoxicity on HL 60 cells could be accounted for by an impairment of its uptake. After 250 ng/ml DNR treatment for 30 min, the time course of Ara-C uptake was measured, up to 128 min of incubation at 37°C and at 4°C, compared with controls. We found that DNR inhibits Ara-C uptake both at 37 and 4°C, mostly acting on passive diffusion.",

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pages = "436--440",

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T1 - Daunorubicin impairs 1-beta-D-arabinofuranosylcytosine uptake

AU - Dal Pozzo, O.

AU - Bernabei, P. A.

AU - Lombardini, L.

AU - Fenigli, S.

AU - D'Ippolito, G.

AU - Ferrini, P. R.

PY - 1991

Y1 - 1991

N2 - Daunorubicin (DNR) and 1-β-D-arabinofuranosylcytosine (Ara-C) act in a schedule-dependent fashion on leukemic cells. The present study was undertaken to determine whether the inhibition exerted by DNR on Ara-C cytotoxicity on HL 60 cells could be accounted for by an impairment of its uptake. After 250 ng/ml DNR treatment for 30 min, the time course of Ara-C uptake was measured, up to 128 min of incubation at 37°C and at 4°C, compared with controls. We found that DNR inhibits Ara-C uptake both at 37 and 4°C, mostly acting on passive diffusion.

AB - Daunorubicin (DNR) and 1-β-D-arabinofuranosylcytosine (Ara-C) act in a schedule-dependent fashion on leukemic cells. The present study was undertaken to determine whether the inhibition exerted by DNR on Ara-C cytotoxicity on HL 60 cells could be accounted for by an impairment of its uptake. After 250 ng/ml DNR treatment for 30 min, the time course of Ara-C uptake was measured, up to 128 min of incubation at 37°C and at 4°C, compared with controls. We found that DNR inhibits Ara-C uptake both at 37 and 4°C, mostly acting on passive diffusion.

KW - 1-β-D-arabinofuranosylcytosine

KW - Daunorubicin

KW - Scheduling-dependent effect Antitumor drugs

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Daunorubicin impairs 1-beta-D-arabinofuranosylcytosine uptake

Abstract

Keywords

ASJC Scopus subject areas

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