Abstract
Daunorubicin (DNR) and 1-β-D-arabinofuranosylcytosine (Ara-C) act in a schedule-dependent fashion on leukemic cells. The present study was undertaken to determine whether the inhibition exerted by DNR on Ara-C cytotoxicity on HL 60 cells could be accounted for by an impairment of its uptake. After 250 ng/ml DNR treatment for 30 min, the time course of Ara-C uptake was measured, up to 128 min of incubation at 37°C and at 4°C, compared with controls. We found that DNR inhibits Ara-C uptake both at 37 and 4°C, mostly acting on passive diffusion.
Original language | English (US) |
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Pages (from-to) | 436-440 |
Number of pages | 5 |
Journal | Chemotherapy |
Volume | 37 |
Issue number | 6 |
DOIs | |
State | Published - 1991 |
Keywords
- 1-β-D-arabinofuranosylcytosine
- Daunorubicin
- Scheduling-dependent effect Antitumor drugs
ASJC Scopus subject areas
- Pharmacology (medical)