Daunorubicin impairs 1-beta-D-arabinofuranosylcytosine uptake

O. Dal Pozzo, P. A. Bernabei, L. Lombardini, S. Fenigli, G. D'Ippolito, P. R. Ferrini

Research output: Contribution to journalArticle

Abstract

Daunorubicin (DNR) and 1-β-D-arabinofuranosylcytosine (Ara-C) act in a schedule-dependent fashion on leukemic cells. The present study was undertaken to determine whether the inhibition exerted by DNR on Ara-C cytotoxicity on HL 60 cells could be accounted for by an impairment of its uptake. After 250 ng/ml DNR treatment for 30 min, the time course of Ara-C uptake was measured, up to 128 min of incubation at 37°C and at 4°C, compared with controls. We found that DNR inhibits Ara-C uptake both at 37 and 4°C, mostly acting on passive diffusion.

Original languageEnglish (US)
Pages (from-to)436-440
Number of pages5
JournalChemotherapy
Volume37
Issue number6
DOIs
StatePublished - Jan 1 1991

Keywords

  • 1-β-D-arabinofuranosylcytosine
  • Daunorubicin
  • Scheduling-dependent effect Antitumor drugs

ASJC Scopus subject areas

  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Daunorubicin impairs 1-beta-D-arabinofuranosylcytosine uptake'. Together they form a unique fingerprint.

  • Cite this

    Dal Pozzo, O., Bernabei, P. A., Lombardini, L., Fenigli, S., D'Ippolito, G., & Ferrini, P. R. (1991). Daunorubicin impairs 1-beta-D-arabinofuranosylcytosine uptake. Chemotherapy, 37(6), 436-440. https://doi.org/10.1159/000238891