Abstract
The effects of acute administration of Danazol on the basal serum levels and pituitary content of LH and FSH and on the release of gonadotropins induced by LH-RH in immature male rats were studied. The basal serum levels of LH and FSH were diminished by Danazol, but the pituitary contant of gonadotropin was not. Danazol injected once a day in the dose of 4 mg/rat for 3 days significantly (P < 0.001) inhibited the LH and FSH response to LH-RH. A single injection of Danazol was enough to produce this inhibition of LH and FSH release if this compound was given at least 4 hours before LH-RH. The results indicate that Danazol interferes with the effect of endogenous LH-RH on the pituitary gonadotropins and that this might be one of the mechanisms for its contraceptive action.
Original language | English (US) |
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Pages (from-to) | 61-69 |
Number of pages | 9 |
Journal | Contraception |
Volume | 17 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1978 |
Externally published | Yes |
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology