Danazol effects on gowadotrop in basal levels and pituitary responsiveness to lh-rn in immature male rats

E. Pedroza, J. A. Vilchez-Martinez, A. Arimura, Andrew V Schally

Research output: Contribution to journalArticle

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Abstract

The effects of acute administration of Danazol on the basal serum levels and pituitary content of LH and FSH and on the release of gonadotropins induced by LH-RH in immature male rats were studied. The basal serum levels of LH and FSH were diminished by Danazol, but the pituitary contant of gonadotropin was not. Danazol injected once a day in the dose of 4 mg/rat for 3 days significantly (P < 0.001) inhibited the LH and FSH response to LH-RH. A single injection of Danazol was enough to produce this inhibition of LH and FSH release if this compound was given at least 4 hours before LH-RH. The results indicate that Danazol interferes with the effect of endogenous LH-RH on the pituitary gonadotropins and that this might be one of the mechanisms for its contraceptive action.

Original languageEnglish
Pages (from-to)61-69
Number of pages9
JournalContraception
Volume17
Issue number1
DOIs
StatePublished - Jan 1 1978
Externally publishedYes

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Danazol
Gonadotropin-Releasing Hormone
Pituitary Gonadotropins
Contraceptive Agents
Serum
Gonadotropins
Injections

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Danazol effects on gowadotrop in basal levels and pituitary responsiveness to lh-rn in immature male rats. / Pedroza, E.; Vilchez-Martinez, J. A.; Arimura, A.; Schally, Andrew V.

In: Contraception, Vol. 17, No. 1, 01.01.1978, p. 61-69.

Research output: Contribution to journalArticle

Pedroza, E. ; Vilchez-Martinez, J. A. ; Arimura, A. ; Schally, Andrew V. / Danazol effects on gowadotrop in basal levels and pituitary responsiveness to lh-rn in immature male rats. In: Contraception. 1978 ; Vol. 17, No. 1. pp. 61-69.
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