Abstract
The effects of acute administration of Danazol on the basal serum levels and pituitary content of LH and FSH and on the release of gonadotropins induced by LH-RH in immature male rats were studied. The basal serum levels of LH and FSH were diminished by Danazol, but the pituitary contant of gonadotropin was not. Danazol injected once a day in the dose of 4 mg/rat for 3 days significantly (P < 0.001) inhibited the LH and FSH response to LH-RH. A single injection of Danazol was enough to produce this inhibition of LH and FSH release if this compound was given at least 4 hours before LH-RH. The results indicate that Danazol interferes with the effect of endogenous LH-RH on the pituitary gonadotropins and that this might be one of the mechanisms for its contraceptive action.
| Original language | English |
|---|---|
| Pages (from-to) | 61-69 |
| Number of pages | 9 |
| Journal | Contraception |
| Volume | 17 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1978 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Medicine(all)
- Obstetrics and Gynecology
Cite this
Danazol effects on gowadotrop in basal levels and pituitary responsiveness to lh-rn in immature male rats. / Pedroza, E.; Vilchez-Martinez, J. A.; Arimura, A.; Schally, Andrew V.
In: Contraception, Vol. 17, No. 1, 01.01.1978, p. 61-69.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Danazol effects on gowadotrop in basal levels and pituitary responsiveness to lh-rn in immature male rats
AU - Pedroza, E.
AU - Vilchez-Martinez, J. A.
AU - Arimura, A.
AU - Schally, Andrew V
PY - 1978/1/1
Y1 - 1978/1/1
N2 - The effects of acute administration of Danazol on the basal serum levels and pituitary content of LH and FSH and on the release of gonadotropins induced by LH-RH in immature male rats were studied. The basal serum levels of LH and FSH were diminished by Danazol, but the pituitary contant of gonadotropin was not. Danazol injected once a day in the dose of 4 mg/rat for 3 days significantly (P < 0.001) inhibited the LH and FSH response to LH-RH. A single injection of Danazol was enough to produce this inhibition of LH and FSH release if this compound was given at least 4 hours before LH-RH. The results indicate that Danazol interferes with the effect of endogenous LH-RH on the pituitary gonadotropins and that this might be one of the mechanisms for its contraceptive action.
AB - The effects of acute administration of Danazol on the basal serum levels and pituitary content of LH and FSH and on the release of gonadotropins induced by LH-RH in immature male rats were studied. The basal serum levels of LH and FSH were diminished by Danazol, but the pituitary contant of gonadotropin was not. Danazol injected once a day in the dose of 4 mg/rat for 3 days significantly (P < 0.001) inhibited the LH and FSH response to LH-RH. A single injection of Danazol was enough to produce this inhibition of LH and FSH release if this compound was given at least 4 hours before LH-RH. The results indicate that Danazol interferes with the effect of endogenous LH-RH on the pituitary gonadotropins and that this might be one of the mechanisms for its contraceptive action.
UR - http://www.scopus.com/inward/record.url?scp=0018101418&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018101418&partnerID=8YFLogxK
U2 - 10.1016/0010-7824(78)90061-6
DO - 10.1016/0010-7824(78)90061-6
M3 - Article
C2 - 342188
AN - SCOPUS:0018101418
VL - 17
SP - 61
EP - 69
JO - Contraception
JF - Contraception
SN - 0010-7824
IS - 1
ER -