Danazol effects on gowadotrop in basal levels and pituitary responsiveness to lh-rn in immature male rats

E. Pedroza; J. A. Vilchez-Martinez; A. Arimura; A. V. Schally

doi:10.1016/0010-7824(78)90061-6

Danazol effects on gowadotrop in basal levels and pituitary responsiveness to lh-rn in immature male rats

E. Pedroza, J. A. Vilchez-Martinez, A. Arimura, A. V. Schally

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The effects of acute administration of Danazol on the basal serum levels and pituitary content of LH and FSH and on the release of gonadotropins induced by LH-RH in immature male rats were studied. The basal serum levels of LH and FSH were diminished by Danazol, but the pituitary contant of gonadotropin was not. Danazol injected once a day in the dose of 4 mg/rat for 3 days significantly (P < 0.001) inhibited the LH and FSH response to LH-RH. A single injection of Danazol was enough to produce this inhibition of LH and FSH release if this compound was given at least 4 hours before LH-RH. The results indicate that Danazol interferes with the effect of endogenous LH-RH on the pituitary gonadotropins and that this might be one of the mechanisms for its contraceptive action.

Original language	English (US)
Pages (from-to)	61-69
Number of pages	9
Journal	Contraception
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/0010-7824(78)90061-6
State	Published - Jan 1978
Externally published	Yes

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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@article{b8f2d07f8fce43d6b589e1c75d83369d,

title = "Danazol effects on gowadotrop in basal levels and pituitary responsiveness to lh-rn in immature male rats",

abstract = "The effects of acute administration of Danazol on the basal serum levels and pituitary content of LH and FSH and on the release of gonadotropins induced by LH-RH in immature male rats were studied. The basal serum levels of LH and FSH were diminished by Danazol, but the pituitary contant of gonadotropin was not. Danazol injected once a day in the dose of 4 mg/rat for 3 days significantly (P < 0.001) inhibited the LH and FSH response to LH-RH. A single injection of Danazol was enough to produce this inhibition of LH and FSH release if this compound was given at least 4 hours before LH-RH. The results indicate that Danazol interferes with the effect of endogenous LH-RH on the pituitary gonadotropins and that this might be one of the mechanisms for its contraceptive action.",

author = "E. Pedroza and Vilchez-Martinez, {J. A.} and A. Arimura and Schally, {A. V.}",

note = "Funding Information: This vork uas supported by NICHIUI contract 72-2741, IJSPHS Grants TS hHD7567, AMb9D9h, HD fb6555 and Veterans Administration. The authors thank firs. J. Gauthier and Mrs. D. Pierson for their t&ical help, Dr. G. Nisweoder and Dr. D.N. Ward and NiAJtDO rat Pituitary Hornmoe Program for gifts of material used in radio-inaumoassays. and ye are especially grateful to Dr. 6.0. Potts of Sterling Yinthrap Research Institute for his kind supply of Danazoi and I his valuable advice. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1978",

month = jan,

doi = "10.1016/0010-7824(78)90061-6",

language = "English (US)",

volume = "17",

pages = "61--69",

journal = "Contraception",

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number = "1",

}

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T1 - Danazol effects on gowadotrop in basal levels and pituitary responsiveness to lh-rn in immature male rats

AU - Pedroza, E.

AU - Vilchez-Martinez, J. A.

AU - Arimura, A.

AU - Schally, A. V.

N1 - Funding Information: This vork uas supported by NICHIUI contract 72-2741, IJSPHS Grants TS hHD7567, AMb9D9h, HD fb6555 and Veterans Administration. The authors thank firs. J. Gauthier and Mrs. D. Pierson for their t&ical help, Dr. G. Nisweoder and Dr. D.N. Ward and NiAJtDO rat Pituitary Hornmoe Program for gifts of material used in radio-inaumoassays. and ye are especially grateful to Dr. 6.0. Potts of Sterling Yinthrap Research Institute for his kind supply of Danazoi and I his valuable advice. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1978/1

Y1 - 1978/1

N2 - The effects of acute administration of Danazol on the basal serum levels and pituitary content of LH and FSH and on the release of gonadotropins induced by LH-RH in immature male rats were studied. The basal serum levels of LH and FSH were diminished by Danazol, but the pituitary contant of gonadotropin was not. Danazol injected once a day in the dose of 4 mg/rat for 3 days significantly (P < 0.001) inhibited the LH and FSH response to LH-RH. A single injection of Danazol was enough to produce this inhibition of LH and FSH release if this compound was given at least 4 hours before LH-RH. The results indicate that Danazol interferes with the effect of endogenous LH-RH on the pituitary gonadotropins and that this might be one of the mechanisms for its contraceptive action.

AB - The effects of acute administration of Danazol on the basal serum levels and pituitary content of LH and FSH and on the release of gonadotropins induced by LH-RH in immature male rats were studied. The basal serum levels of LH and FSH were diminished by Danazol, but the pituitary contant of gonadotropin was not. Danazol injected once a day in the dose of 4 mg/rat for 3 days significantly (P < 0.001) inhibited the LH and FSH response to LH-RH. A single injection of Danazol was enough to produce this inhibition of LH and FSH release if this compound was given at least 4 hours before LH-RH. The results indicate that Danazol interferes with the effect of endogenous LH-RH on the pituitary gonadotropins and that this might be one of the mechanisms for its contraceptive action.

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