Danazol effects on gowadotrop in basal levels and pituitary responsiveness to lh-rn in immature male rats

E. Pedroza; J. A. Vilchez-Martinez; A. Arimura; A. V. Schally

doi:10.1016/0010-7824(78)90061-6

Danazol effects on gowadotrop in basal levels and pituitary responsiveness to lh-rn in immature male rats

E. Pedroza, J. A. Vilchez-Martinez, A. Arimura, A. V. Schally

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Abstract

The effects of acute administration of Danazol on the basal serum levels and pituitary content of LH and FSH and on the release of gonadotropins induced by LH-RH in immature male rats were studied. The basal serum levels of LH and FSH were diminished by Danazol, but the pituitary contant of gonadotropin was not. Danazol injected once a day in the dose of 4 mg/rat for 3 days significantly (P < 0.001) inhibited the LH and FSH response to LH-RH. A single injection of Danazol was enough to produce this inhibition of LH and FSH release if this compound was given at least 4 hours before LH-RH. The results indicate that Danazol interferes with the effect of endogenous LH-RH on the pituitary gonadotropins and that this might be one of the mechanisms for its contraceptive action.

Original language	English (US)
Pages (from-to)	61-69
Number of pages	9
Journal	Contraception
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/0010-7824(78)90061-6
State	Published - Jan 1978
Externally published	Yes

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ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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Pedroza, E., Vilchez-Martinez, J. A., Arimura, A., & Schally, A. V. (1978). Danazol effects on gowadotrop in basal levels and pituitary responsiveness to lh-rn in immature male rats. Contraception, 17(1), 61-69. https://doi.org/10.1016/0010-7824(78)90061-6

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AB - The effects of acute administration of Danazol on the basal serum levels and pituitary content of LH and FSH and on the release of gonadotropins induced by LH-RH in immature male rats were studied. The basal serum levels of LH and FSH were diminished by Danazol, but the pituitary contant of gonadotropin was not. Danazol injected once a day in the dose of 4 mg/rat for 3 days significantly (P < 0.001) inhibited the LH and FSH response to LH-RH. A single injection of Danazol was enough to produce this inhibition of LH and FSH release if this compound was given at least 4 hours before LH-RH. The results indicate that Danazol interferes with the effect of endogenous LH-RH on the pituitary gonadotropins and that this might be one of the mechanisms for its contraceptive action.

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10.1016/0010-7824(78)90061-6