Danazol effects on gowadotrop in basal levels and pituitary responsiveness to lh-rn in immature male rats

E. Pedroza; J. A. Vilchez-Martinez; A. Arimura; A. V. Schally

doi:10.1016/0010-7824(78)90061-6

Danazol effects on gowadotrop in basal levels and pituitary responsiveness to lh-rn in immature male rats

E. Pedroza, J. A. Vilchez-Martinez, A. Arimura, A. V. Schally

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Abstract

The effects of acute administration of Danazol on the basal serum levels and pituitary content of LH and FSH and on the release of gonadotropins induced by LH-RH in immature male rats were studied. The basal serum levels of LH and FSH were diminished by Danazol, but the pituitary contant of gonadotropin was not. Danazol injected once a day in the dose of 4 mg/rat for 3 days significantly (P < 0.001) inhibited the LH and FSH response to LH-RH. A single injection of Danazol was enough to produce this inhibition of LH and FSH release if this compound was given at least 4 hours before LH-RH. The results indicate that Danazol interferes with the effect of endogenous LH-RH on the pituitary gonadotropins and that this might be one of the mechanisms for its contraceptive action.

Original language	English (US)
Pages (from-to)	61-69
Number of pages	9
Journal	Contraception
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/0010-7824(78)90061-6
State	Published - Jan 1978
Externally published	Yes

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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title = "Danazol effects on gowadotrop in basal levels and pituitary responsiveness to lh-rn in immature male rats",

abstract = "The effects of acute administration of Danazol on the basal serum levels and pituitary content of LH and FSH and on the release of gonadotropins induced by LH-RH in immature male rats were studied. The basal serum levels of LH and FSH were diminished by Danazol, but the pituitary contant of gonadotropin was not. Danazol injected once a day in the dose of 4 mg/rat for 3 days significantly (P < 0.001) inhibited the LH and FSH response to LH-RH. A single injection of Danazol was enough to produce this inhibition of LH and FSH release if this compound was given at least 4 hours before LH-RH. The results indicate that Danazol interferes with the effect of endogenous LH-RH on the pituitary gonadotropins and that this might be one of the mechanisms for its contraceptive action.",

author = "E. Pedroza and Vilchez-Martinez, {J. A.} and A. Arimura and Schally, {A. V.}",

note = "Funding Information: This vork uas supported by NICHIUI contract 72-2741, IJSPHS Grants TS hHD7567, AMb9D9h, HD fb6555 and Veterans Administration. The authors thank firs. J. Gauthier and Mrs. D. Pierson for their t&ical help, Dr. G. Nisweoder and Dr. D.N. Ward and NiAJtDO rat Pituitary Hornmoe Program for gifts of material used in radio-inaumoassays. and ye are especially grateful to Dr. 6.0. Potts of Sterling Yinthrap Research Institute for his kind supply of Danazoi and I his valuable advice. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1978",

month = jan,

doi = "10.1016/0010-7824(78)90061-6",

language = "English (US)",

volume = "17",

pages = "61--69",

journal = "Contraception",

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T1 - Danazol effects on gowadotrop in basal levels and pituitary responsiveness to lh-rn in immature male rats

AU - Pedroza, E.

AU - Vilchez-Martinez, J. A.

AU - Arimura, A.

AU - Schally, A. V.

N1 - Funding Information: This vork uas supported by NICHIUI contract 72-2741, IJSPHS Grants TS hHD7567, AMb9D9h, HD fb6555 and Veterans Administration. The authors thank firs. J. Gauthier and Mrs. D. Pierson for their t&ical help, Dr. G. Nisweoder and Dr. D.N. Ward and NiAJtDO rat Pituitary Hornmoe Program for gifts of material used in radio-inaumoassays. and ye are especially grateful to Dr. 6.0. Potts of Sterling Yinthrap Research Institute for his kind supply of Danazoi and I his valuable advice. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1978/1

Y1 - 1978/1

N2 - The effects of acute administration of Danazol on the basal serum levels and pituitary content of LH and FSH and on the release of gonadotropins induced by LH-RH in immature male rats were studied. The basal serum levels of LH and FSH were diminished by Danazol, but the pituitary contant of gonadotropin was not. Danazol injected once a day in the dose of 4 mg/rat for 3 days significantly (P < 0.001) inhibited the LH and FSH response to LH-RH. A single injection of Danazol was enough to produce this inhibition of LH and FSH release if this compound was given at least 4 hours before LH-RH. The results indicate that Danazol interferes with the effect of endogenous LH-RH on the pituitary gonadotropins and that this might be one of the mechanisms for its contraceptive action.

AB - The effects of acute administration of Danazol on the basal serum levels and pituitary content of LH and FSH and on the release of gonadotropins induced by LH-RH in immature male rats were studied. The basal serum levels of LH and FSH were diminished by Danazol, but the pituitary contant of gonadotropin was not. Danazol injected once a day in the dose of 4 mg/rat for 3 days significantly (P < 0.001) inhibited the LH and FSH response to LH-RH. A single injection of Danazol was enough to produce this inhibition of LH and FSH release if this compound was given at least 4 hours before LH-RH. The results indicate that Danazol interferes with the effect of endogenous LH-RH on the pituitary gonadotropins and that this might be one of the mechanisms for its contraceptive action.

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Danazol effects on gowadotrop in basal levels and pituitary responsiveness to lh-rn in immature male rats

Abstract

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