Daily cocaine treatment produces a persistent reduction of [3H]dopamine uptake in vitro in rat nucleus accumbens but not in striatum

Sari Izenwasser, Brian M. Cox

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

Daily administration of cocaine (15 mg/kg i.p. × 3 days) led to a decrease in the total amount of 15 nM [3H]dopamine uptake in rat nucleus accumbens with no changes in uptake in the striatum when tested 24 h after the last injection. There was an increase in the Km for dopamine uptake in the nucleus accumbens of cocaine-treated rats, with no change in the Vmax. Furthermore, cocaine was a more potent inhibitor of [3H]dopamine uptake in vitro in the nucleus accumbens of rats treated with cocaine than in those which had received saline.

Original languageEnglish (US)
Pages (from-to)338-341
Number of pages4
JournalBrain Research
Volume531
Issue number1-2
DOIs
StatePublished - Oct 29 1990
Externally publishedYes

Keywords

  • Cocaine
  • Dopamine transport
  • Dopamine uptake
  • Nucleus accumbens
  • Striatum

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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