D-TRP6-ANALOGUE OF LUTEINISING HORMONE RELEASING HORMONE IN COMBINATION WITH CYPROTERONE ACETATE TO TREAT PRECOCIOUS PUBERTY

Zvi Laron, Zvi Ben Zeev, Rivka Kauli, Ana Maria COMARU-SCHALLY, Andrew V. Schally

Research output: Contribution to journalArticle

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Abstract

A 6-year-old girl with central (true) precocious puberty was successfully treated with a combination of the luteinising hormone releasing hormone analogue (D-Trp6)-LH-RH and cyproterone acetate. This treatment led to an almost complete arrest of gonadotrophin and oestrogen secretion, induced regression of pubertal signs, and markedly slowed bone maturation. It is suggested that the paradoxical refractoriness of the gonadotrophic and gonadal cells induced by long-term treatment with LH-RH agonists can be exploited in the treatment of precocious puberty.

Original languageEnglish (US)
Pages (from-to)955-956
Number of pages2
JournalThe Lancet
Volume318
Issue number8253
DOIs
StatePublished - Oct 31 1981
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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