Abstract
Several vaccine studies have ameliorated disease progression in simian-human immunodeficiency virus (SHIV) infections. The successes of these vaccines have been largely attributed to protective effects of cytotoxic T-lymphocyte (CTL) responses, although the precise correlates of immune protection remain poorly defined. It is now well established that vigorous CTL and antibody responses can rapidly select for viral escape variants after HIV and SIV infection. Here we suggest that viral variation analyses should be performed on viruses derived from vaccinated, SIV-, or SHIV-challenged animals as a routine component of vaccine evaluation to determine the contribution of immune responses to the success (or failure) of the vaccine regimen. To illustrate the importance of escape analysis, we show that rapid emergence of escape variants postchallenge contributed to the failure of a DNA prime/MVA boost vaccine regimen encoding SIV Tat.
| Original language | English |
|---|---|
| Pages (from-to) | 659-664 |
| Number of pages | 6 |
| Journal | DNA and Cell Biology |
| Volume | 21 |
| Issue number | 9 |
| DOIs | |
| State | Published - Oct 23 2002 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cell Biology
Cite this
Cytotoxic T-lymphocyte escape monitoring in simian immunodeficiency virus vaccine challenge studies. / O'Connor, David H.; Allen, Todd M.; Watkins, David.
In: DNA and Cell Biology, Vol. 21, No. 9, 23.10.2002, p. 659-664.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cytotoxic T-lymphocyte escape monitoring in simian immunodeficiency virus vaccine challenge studies
AU - O'Connor, David H.
AU - Allen, Todd M.
AU - Watkins, David
PY - 2002/10/23
Y1 - 2002/10/23
N2 - Several vaccine studies have ameliorated disease progression in simian-human immunodeficiency virus (SHIV) infections. The successes of these vaccines have been largely attributed to protective effects of cytotoxic T-lymphocyte (CTL) responses, although the precise correlates of immune protection remain poorly defined. It is now well established that vigorous CTL and antibody responses can rapidly select for viral escape variants after HIV and SIV infection. Here we suggest that viral variation analyses should be performed on viruses derived from vaccinated, SIV-, or SHIV-challenged animals as a routine component of vaccine evaluation to determine the contribution of immune responses to the success (or failure) of the vaccine regimen. To illustrate the importance of escape analysis, we show that rapid emergence of escape variants postchallenge contributed to the failure of a DNA prime/MVA boost vaccine regimen encoding SIV Tat.
AB - Several vaccine studies have ameliorated disease progression in simian-human immunodeficiency virus (SHIV) infections. The successes of these vaccines have been largely attributed to protective effects of cytotoxic T-lymphocyte (CTL) responses, although the precise correlates of immune protection remain poorly defined. It is now well established that vigorous CTL and antibody responses can rapidly select for viral escape variants after HIV and SIV infection. Here we suggest that viral variation analyses should be performed on viruses derived from vaccinated, SIV-, or SHIV-challenged animals as a routine component of vaccine evaluation to determine the contribution of immune responses to the success (or failure) of the vaccine regimen. To illustrate the importance of escape analysis, we show that rapid emergence of escape variants postchallenge contributed to the failure of a DNA prime/MVA boost vaccine regimen encoding SIV Tat.
UR - http://www.scopus.com/inward/record.url?scp=0036397709&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036397709&partnerID=8YFLogxK
U2 - 10.1089/104454902760330192
DO - 10.1089/104454902760330192
M3 - Article
C2 - 12396608
AN - SCOPUS:0036397709
VL - 21
SP - 659
EP - 664
JO - DNA and Cell Biology
JF - DNA and Cell Biology
SN - 1044-5498
IS - 9
ER -