Cytotoxic effects of novel amphiphilic dimers consisting of 5-fluorodeoxyuridine and arabinofuranosylcytosine in cross-resistant H9 human lymphoma cells

Philipp Saiko, Zsuzsanna Horvath, Christoph Illmer, Sibylle Madlener, Wolfgang Bauer, Thomas Hoechtl, Natascha Erlach, Michael Grusch, Georg Krupitza, Robert M. Mader, Walter Jaeger, Herbert Schott, Ram P. Agarwal, Monika Fritzer-Szekeres, Thomas Szekeres

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Various amphiphilic heterodinucleoside phosphates have recently been synthesized in order to overcome drug resistance. These agents contain 5-fluorodeoxyuridine (5-FdUrd) and arabinofuranosylcytosine (Ara-C). We now investigated the action of two of these novel dimers (# 2 and # 10) in sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells. The dimers were compared with 5-FdUrd and Ara-C for growth inhibition, apoptosis induction, and cell-cycle effects. No significant difference in the cytotoxicity of dimer # 2 could be observed between sensitive and 5-FdUrd/Ara-C cross-resistant H9 cells (IC50 values of 220 nM and 200 nM, respectively), indicating that further studies with this compound are warranted.

Original languageEnglish (US)
Pages (from-to)785-791
Number of pages7
JournalLeukemia Research
Volume29
Issue number7
DOIs
StatePublished - Jul 1 2005

Keywords

  • 5-Fluorodeoxyuridine
  • Apoptosis
  • Arabinofuranosylcytosine
  • Cell-cycle
  • Cross-resistance
  • Lymphoma

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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    Saiko, P., Horvath, Z., Illmer, C., Madlener, S., Bauer, W., Hoechtl, T., Erlach, N., Grusch, M., Krupitza, G., Mader, R. M., Jaeger, W., Schott, H., Agarwal, R. P., Fritzer-Szekeres, M., & Szekeres, T. (2005). Cytotoxic effects of novel amphiphilic dimers consisting of 5-fluorodeoxyuridine and arabinofuranosylcytosine in cross-resistant H9 human lymphoma cells. Leukemia Research, 29(7), 785-791. https://doi.org/10.1016/j.leukres.2004.12.015