Cytosolic DNA-Sensing and the STING Pathway

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Invading microbes are detected by cellular sensors, the consequences of which result in the production of potent anti-pathogen proteins such as type I interferon (IFN) as well as other cytokines capable of stimulating the adaptive immune response. Examples comprise the RIG-I-like helicase (RLH) and the Toll-like receptor (TLR) families which recognize non-self-pathogen derived molecules (PAMPs) including bacterial lipopolysaccharides as well as nucleic acids. In addition, an endoplasmic reticulum (ER) associated transmembrane protein referred to as STING (for stimulator of interferon genes) was established as being essential for triggering the production of innate immune proteins in response to the sensing of cytosolic DNA. Such DNA can be 'self'-DNA produced from necrotic or apoptotic cells, or the actual genomes of DNA pathogens that become exposed following infection. Moreover, while STING appears essential for controlling innate signaling events triggered by DNA microbes, chronic STING activation also appears to be responsible for certain inflammatory diseases manifested by 'self'-DNA. Thus, understanding STING function may lead to the design of new compounds that may facilitate vaccine development or conversely that may provide new therapies for the treatment of inflammatory disease.

Original languageEnglish (US)
Title of host publicationBiological DNA Sensor
Subtitle of host publicationThe Impact of Nucleic Acids on Diseases and Vaccinology
PublisherElsevier Inc.
Pages67-81
Number of pages15
ISBN (Print)9780124047327
DOIs
StatePublished - Nov 1 2013

Keywords

  • CGAS
  • Cytosolic DNA
  • DNA pathogens
  • Inflammatory disease
  • Innate immunity
  • STING
  • TBK1

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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  • Cite this

    Barber, G. N. (2013). Cytosolic DNA-Sensing and the STING Pathway. In Biological DNA Sensor: The Impact of Nucleic Acids on Diseases and Vaccinology (pp. 67-81). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-404732-7.00003-4