Cytoplasmic estrogen and progesterone receptors in primary cervical carcinoma: Clinical and histopathologic correlates

Yong Liang Gao, Leo B. Twiggs, Bejamin S. Leung, Winston C.Y.Yu, Roger A. Potish, Takashi Okagaki, Leon L. Adcock, Konald A. Prem

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

From 1977 to 1981, 39 cases of primary cervical carcinoma were assayed for the presence or absence of cytoplasmic estrogen (ERc) and progesterone (PRc) receptors by a saturation point dextran-coated charcoal assay. The levels of ERc and PRc were compared with clinical stage, histologic type, histologic grade, menstrual status, age, and survival. Carcinomas were divided into positive and negative receptor groups with the use of greater than 5 fmol/mg of cytosol protein for ERc and 10 fmol/mg of cytosol protein for PRc as discrimination points. Survival of the patients studied was computed by means of the product-limit analysis according to Kaplan-Meier. A statistically significant difference in survival in the PRc + group versus the PRc - group in the total group of patients was noted with the Mantel-Cox test (P = 0.049). When pateints were stratified according to menopausal status, a statistically significant difference in survival was noted between the PRc + group versus the PRc - group in the premenopausal patients only.

Original languageEnglish
Pages (from-to)299-306
Number of pages8
JournalAmerican Journal of Obstetrics and Gynecology
Volume146
Issue number3
StatePublished - Jun 1 1983
Externally publishedYes

Fingerprint

Progesterone Receptors
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Carcinoma
Survival
Cytosol
Charcoal
Dextrans
Estrogens
Proteins

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Gao, Y. L., Twiggs, L. B., Leung, B. S., C.Y.Yu, W., Potish, R. A., Okagaki, T., ... Prem, K. A. (1983). Cytoplasmic estrogen and progesterone receptors in primary cervical carcinoma: Clinical and histopathologic correlates. American Journal of Obstetrics and Gynecology, 146(3), 299-306.

Cytoplasmic estrogen and progesterone receptors in primary cervical carcinoma : Clinical and histopathologic correlates. / Gao, Yong Liang; Twiggs, Leo B.; Leung, Bejamin S.; C.Y.Yu, Winston; Potish, Roger A.; Okagaki, Takashi; Adcock, Leon L.; Prem, Konald A.

In: American Journal of Obstetrics and Gynecology, Vol. 146, No. 3, 01.06.1983, p. 299-306.

Research output: Contribution to journalArticle

Gao, YL, Twiggs, LB, Leung, BS, C.Y.Yu, W, Potish, RA, Okagaki, T, Adcock, LL & Prem, KA 1983, 'Cytoplasmic estrogen and progesterone receptors in primary cervical carcinoma: Clinical and histopathologic correlates', American Journal of Obstetrics and Gynecology, vol. 146, no. 3, pp. 299-306.
Gao, Yong Liang ; Twiggs, Leo B. ; Leung, Bejamin S. ; C.Y.Yu, Winston ; Potish, Roger A. ; Okagaki, Takashi ; Adcock, Leon L. ; Prem, Konald A. / Cytoplasmic estrogen and progesterone receptors in primary cervical carcinoma : Clinical and histopathologic correlates. In: American Journal of Obstetrics and Gynecology. 1983 ; Vol. 146, No. 3. pp. 299-306.
@article{3c84b8254ba249b7baa660ab883ab205,
title = "Cytoplasmic estrogen and progesterone receptors in primary cervical carcinoma: Clinical and histopathologic correlates",
abstract = "From 1977 to 1981, 39 cases of primary cervical carcinoma were assayed for the presence or absence of cytoplasmic estrogen (ERc) and progesterone (PRc) receptors by a saturation point dextran-coated charcoal assay. The levels of ERc and PRc were compared with clinical stage, histologic type, histologic grade, menstrual status, age, and survival. Carcinomas were divided into positive and negative receptor groups with the use of greater than 5 fmol/mg of cytosol protein for ERc and 10 fmol/mg of cytosol protein for PRc as discrimination points. Survival of the patients studied was computed by means of the product-limit analysis according to Kaplan-Meier. A statistically significant difference in survival in the PRc + group versus the PRc - group in the total group of patients was noted with the Mantel-Cox test (P = 0.049). When pateints were stratified according to menopausal status, a statistically significant difference in survival was noted between the PRc + group versus the PRc - group in the premenopausal patients only.",
author = "Gao, {Yong Liang} and Twiggs, {Leo B.} and Leung, {Bejamin S.} and Winston C.Y.Yu and Potish, {Roger A.} and Takashi Okagaki and Adcock, {Leon L.} and Prem, {Konald A.}",
year = "1983",
month = "6",
day = "1",
language = "English",
volume = "146",
pages = "299--306",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - Cytoplasmic estrogen and progesterone receptors in primary cervical carcinoma

T2 - Clinical and histopathologic correlates

AU - Gao, Yong Liang

AU - Twiggs, Leo B.

AU - Leung, Bejamin S.

AU - C.Y.Yu, Winston

AU - Potish, Roger A.

AU - Okagaki, Takashi

AU - Adcock, Leon L.

AU - Prem, Konald A.

PY - 1983/6/1

Y1 - 1983/6/1

N2 - From 1977 to 1981, 39 cases of primary cervical carcinoma were assayed for the presence or absence of cytoplasmic estrogen (ERc) and progesterone (PRc) receptors by a saturation point dextran-coated charcoal assay. The levels of ERc and PRc were compared with clinical stage, histologic type, histologic grade, menstrual status, age, and survival. Carcinomas were divided into positive and negative receptor groups with the use of greater than 5 fmol/mg of cytosol protein for ERc and 10 fmol/mg of cytosol protein for PRc as discrimination points. Survival of the patients studied was computed by means of the product-limit analysis according to Kaplan-Meier. A statistically significant difference in survival in the PRc + group versus the PRc - group in the total group of patients was noted with the Mantel-Cox test (P = 0.049). When pateints were stratified according to menopausal status, a statistically significant difference in survival was noted between the PRc + group versus the PRc - group in the premenopausal patients only.

AB - From 1977 to 1981, 39 cases of primary cervical carcinoma were assayed for the presence or absence of cytoplasmic estrogen (ERc) and progesterone (PRc) receptors by a saturation point dextran-coated charcoal assay. The levels of ERc and PRc were compared with clinical stage, histologic type, histologic grade, menstrual status, age, and survival. Carcinomas were divided into positive and negative receptor groups with the use of greater than 5 fmol/mg of cytosol protein for ERc and 10 fmol/mg of cytosol protein for PRc as discrimination points. Survival of the patients studied was computed by means of the product-limit analysis according to Kaplan-Meier. A statistically significant difference in survival in the PRc + group versus the PRc - group in the total group of patients was noted with the Mantel-Cox test (P = 0.049). When pateints were stratified according to menopausal status, a statistically significant difference in survival was noted between the PRc + group versus the PRc - group in the premenopausal patients only.

UR - http://www.scopus.com/inward/record.url?scp=0020567590&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020567590&partnerID=8YFLogxK

M3 - Article

C2 - 6859140

AN - SCOPUS:0020567590

VL - 146

SP - 299

EP - 306

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 3

ER -