Cytoplasmic estrogen and progesterone receptors as prognostic parameters in primary endometrial carcinoma

B. S. Liao, L. B. Twiggs, B. S. Leung, W. C. Yu, R. A. Potish, K. A. Prem

Research output: Contribution to journalArticle

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Abstract

Eighty-six cases of primary endometrial carcinoma were assayed for the presence or absence of cytoplasmic estrogen and progesterone receptors by the saturation point dextrancoated charcoal assay. The levels of chytoplasmic progesterone receptors and estrogen receptors were analyzed according to clinical stage, histologic type and grade of the tumor, presence or absence of lymph node metastases, myometrial invasion, and survival. The cases were divided into positive and negative receptor groups with levels chosen of greater than 10 fmol/mg of cytosol protein for progesterone receptor and 5 fmol/mg of cytosol protein for estrogen receptor as discrimination points. Statistically significant survival differences were found between estrogen receptor positive versus estrogen receptor negative patients, progesterone receptor positive versus progesterone receptor negative patients, and estrogen positive-progesterone receptor positive versus estrogen negative-progesterone receptor negative patients. Mean cytoplasmic estrogen and progesterone receptor levels were inversely proportional to grade. This report suggests that treatment protocols should be devised to reflect the prognostic significance of receptor status.

Original languageEnglish
Pages (from-to)463-467
Number of pages5
JournalObstetrics and Gynecology
Volume67
Issue number4
StatePublished - Jul 30 1986
Externally publishedYes

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Progesterone Receptors
Endometrial Neoplasms
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Cytosol
Estrogens
Survival
Charcoal
Clinical Protocols
Lymph Nodes
Neoplasm Metastasis

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Liao, B. S., Twiggs, L. B., Leung, B. S., Yu, W. C., Potish, R. A., & Prem, K. A. (1986). Cytoplasmic estrogen and progesterone receptors as prognostic parameters in primary endometrial carcinoma. Obstetrics and Gynecology, 67(4), 463-467.

Cytoplasmic estrogen and progesterone receptors as prognostic parameters in primary endometrial carcinoma. / Liao, B. S.; Twiggs, L. B.; Leung, B. S.; Yu, W. C.; Potish, R. A.; Prem, K. A.

In: Obstetrics and Gynecology, Vol. 67, No. 4, 30.07.1986, p. 463-467.

Research output: Contribution to journalArticle

Liao, BS, Twiggs, LB, Leung, BS, Yu, WC, Potish, RA & Prem, KA 1986, 'Cytoplasmic estrogen and progesterone receptors as prognostic parameters in primary endometrial carcinoma', Obstetrics and Gynecology, vol. 67, no. 4, pp. 463-467.
Liao BS, Twiggs LB, Leung BS, Yu WC, Potish RA, Prem KA. Cytoplasmic estrogen and progesterone receptors as prognostic parameters in primary endometrial carcinoma. Obstetrics and Gynecology. 1986 Jul 30;67(4):463-467.
Liao, B. S. ; Twiggs, L. B. ; Leung, B. S. ; Yu, W. C. ; Potish, R. A. ; Prem, K. A. / Cytoplasmic estrogen and progesterone receptors as prognostic parameters in primary endometrial carcinoma. In: Obstetrics and Gynecology. 1986 ; Vol. 67, No. 4. pp. 463-467.
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