Cytomegalovirus prevalence and transmission after islet allograft transplant in patients with type 1 diabetes mellitus

Muhammad M. Hafiz, Raffaella Poggioli, Aileen Caulfield, Shari Messinger, Milene C. Geiger, David A. Baidal, Tatiana Froud, Jacqueline V. Ferreira, Andreas G. Tzakis, Camillo Ricordi, Rodolfo Alejandro

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18 Scopus citations

Abstract

Cytomegalovirus (CMV) serological status of transplant donors and recipients has important implications on antiviral prophylaxis, morbidity/mortality, donor selection and hospital stay. We evaluated CMV prevalence in our islet transplant candidates (ITC) in comparison with organ donors. We correlated the CMV serological status of our ITC with serology for Epstein-Barr virus and Parvovirus B19, auto-antibodies, patient's age, age at DM onset, duration of DM, gender, race, ABO group, HLA haplotype and C-peptide levels. Cytomegalovirus transmission after islet transplant using the Edmonton regimen was also evaluated. Cytomegalovirus seropositivity varied according to patient group, age, gender and race. Type 1 DM patients had reduced odds of CMV seropositivity when compared with organ donors. In all groups studied, older patients, females, and non-Caucasians were more likely to be CMV seropositive. In addition, no CMV reactivation, infection or disease was observed among our transplanted patients using this steroid-free regimen even after donor/recipient CMV mismatch.

Original languageEnglish (US)
Pages (from-to)1697-1702
Number of pages6
JournalAmerican Journal of Transplantation
Volume4
Issue number10
DOIs
StatePublished - Oct 1 2004

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Keywords

  • Cytomegalovirus
  • Islet transplant
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Immunology

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