Although cytomegalovirus (CMV) is commonly found in the lungs of patients with acquired immunodeficiency syndrome (AIDS), CMV is an infrequent cause of pneumonia in AIDS. We describe an unusual case of proven CMV pneumonia in an AIDS patient that manifested as a large mass on chest radiography and computed tomography. The mass regressed on antiviral therapy. CMV pneumonia should be included in the differential diagnosis of a lung mass in patients with AIDS.
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