Cytologic differentiation of struma ovarii from other ovarian neoplasms

Yahya Daneshbod, Khosrow Daneshbod, Ali Reza Rasekhi, Ziba Mosayebi, Shahrzad Negahban, Saeed Reza Hodjati, Gholam Reza Bedayat, Parvin Ganjei-Azar

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Objective: To present the cytologic findings of struma ovarii and value of cytology and immunocytochemistry (ICC) using thyroglobulin (TGB) and thyroid transcription factor-1 (TTF-1) in evaluation of this unusual ovarian neoplasm, together with the diagnostic pitfalls. Study Design: Intraoperative cytologic findings of 7 patients with struma ovarii are reviewed. Cytologic material of both cystic and solid components was collected intraoperatively. ICC staining was done, and cell block preparation performed on selected cases. Results: The cases were divided in to 3 groups: group 1 - diagnosis of struma ovarii was made by cytology and confirmed by ICC (1 case); group2 - diagnosis was suggestive on cytology or cell block and confirmed by ICC staining (4 cases); group 3 - on cytologic diagnosis indistinguishable from other cystic ovarian neoplasms (2 cases). Cytologic findings were typically colloid with mosaic pattern, follicles, follicular cells only, sheets of follicular cells, both colloid and follicular cells, proteinaceous background or degenerated epithelial cells indistinguishable from other cystic ovarian neoplasms. Conclusion: Cytologic findings of struma ovarii are distinct enough to be suggested intra operatively, and ICC for TGB or TTF-1 is a valuable tool for preoperative fine needle aspiration biopsy and intraoperative diagnosis of this benign ovarian neoplasm.

Original languageEnglish (US)
Pages (from-to)72-76
Number of pages5
JournalActa Cytologica
Issue number1
StatePublished - 2008


  • Aspiration, fine needle
  • Cytology
  • Immunocytochemistry
  • Ovarian cystic neoplasm
  • Struma ovarii, teratoma

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology
  • Histology


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