Cytokines, obesity, and cancer: New insights on mechanisms linking obesity to cancer risk and progression

Candace A. Gilbert, Joyce M. Slingerland

Research output: Contribution to journalReview article

153 Scopus citations

Abstract

Obesity is a problem of epidemic proportions in many developed nations. Increased body mass index and obesity are associated with a significantly worse outcome for many cancers. Breast cancer risk in the postmenopausal setting and poor disease outcome for all patients is significantly augmented in overweight and obese individuals. The expansion of fat tissue involves a complex interaction of endocrine factors known as adipokines and cytokines. High cytokine levels in primary breast cancers and in the circulation of affected patients have been associated with poor outcome. This review summarizes the how cytokine production in obese adipose tissue creates a chronic inflammatory microenvironment that favors tumor cellmotility, invasion, and epithelialmesenchymal transition to enhance the metastatic potential of tumor cells.Many of the cytokines associated with a proinflammatory state are not only upregulated in obese adipose tissue but may also stimulate the self-renewal of cancer stem cells. Thus, enhanced cytokine production in obese adipose tissuemay serve both as a chemoattractant for invading cancers and to augment their malignant potential. These new mechanistic insights suggest that the current obesity epidemic will presage a significant increase in cancer incidence, morbidity, and mortality in the next few decades.

Original languageEnglish (US)
Pages (from-to)45-57
Number of pages13
JournalAnnual review of medicine
Volume64
DOIs
StatePublished - Jan 14 2013

Keywords

  • adipocytes
  • body mass index
  • breast cancer
  • metastasis

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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