Cytokines and neurodevelopmental outcomes in extremely low birth weight infants

Waldemar A. Carlo, Scott A. McDonald, Jon E. Tyson, Barbara J. Stoll, Richard A. Ehrenkranz, Seetha Shankaran, Ronald N. Goldberg, Abhik Das, Diana Schendel, Poul Thorsen, Kristin Skogstrand, David M. Hougaard, William Oh, Abbot R. Laptook, Shahnaz Duara, Avroy A. Fanaroff, Edward F. Donovan, Sheldon B. Korones, David K. Stevenson, Lu Ann PapileNeil N. Finer, T. Michael O'Shea, Brenda B. Poindexter, Linda L. Wright, Namasivayam Ambalavanan, Rosemary D. Higgins

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Objective: To determine if selected pro-inflammatory and anti-inflammatory cytokines and/or mediators of inflammation reported to be related to the development of cerebral palsy (CP) predict neurodevelopmental outcome in extremely low birth weight infants. Study design: Infants with birth weights ≤1000 g (n = 1067) had blood samples collected at birth and on days 3 ± 1, 7 ± 1, 14 ± 3, and 21 ± 3 to examine the association between cytokines and neurodevelopmental outcomes. The analyses were focused on 5 cytokines (interleukin [IL] 1β; IL-8; tumor necrosis factor-α; regulated upon activation, normal T-cell expressed, and secreted (RANTES); and IL-2) reported to be most predictive of CP in term and late preterm infants. Results: IL-8 was higher on days 0-4 and subsequently in infants who developed CP compared with infants who did not develop CP in both unadjusted and adjusted analyses. Other cytokines (IL-12, IL-17, tumor necrosis factor-β, soluble IL rα, macrophage inflammatory protein 1β) were found to be altered on days 0-4 in infants who developed CP. Conclusions: CP in former preterm infants may, in part, have a late perinatal and/or early neonatal inflammatory origin.

Original languageEnglish (US)
Pages (from-to)919-925.e3
JournalJournal of Pediatrics
Issue number6
StatePublished - Dec 2011

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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