TY - JOUR
T1 - Cytokines and neurodevelopmental outcomes in extremely low birth weight infants
AU - Carlo, Waldemar A.
AU - McDonald, Scott A.
AU - Tyson, Jon E.
AU - Stoll, Barbara J.
AU - Ehrenkranz, Richard A.
AU - Shankaran, Seetha
AU - Goldberg, Ronald N.
AU - Das, Abhik
AU - Schendel, Diana
AU - Thorsen, Poul
AU - Skogstrand, Kristin
AU - Hougaard, David M.
AU - Oh, William
AU - Laptook, Abbot R.
AU - Duara, Shahnaz
AU - Fanaroff, Avroy A.
AU - Donovan, Edward F.
AU - Korones, Sheldon B.
AU - Stevenson, David K.
AU - Papile, Lu Ann
AU - Finer, Neil N.
AU - O'Shea, T. Michael
AU - Poindexter, Brenda B.
AU - Wright, Linda L.
AU - Ambalavanan, Namasivayam
AU - Higgins, Rosemary D.
N1 - Funding Information:
Supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development and the Department of Health and Human Services (U10 HD21385, U10 HD40689, U10 HD27871, U10 HD21373, U01 HD36790, U10 HD40498, U10 HD40461, U10 HD34216, U10 HD21397, U10 HD27904, U10 HD40492, U10 HD27856, U10 HD40521, U10 HD27853, U10 HD27880, U10 HD27851, and R03 HD054420) and from the National Institutes of Health (GCRC M01 RR 08084, M01 RR 00125, M01 RR 00750, M01 RR 00070, M01 RR 0039-43, M01 RR 00039, and 5 M01 RR00044). The National Institutes of Health, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the Centers for Disease Control and Prevention provided grant support for recruitment for 1999-2001 and data analysis for the Neonatal Research Network’s Cytokines Study. The funding agencies provided overall oversight for study conduct, but all data analyses and interpretation were independent of the funding agencies.
PY - 2011/12
Y1 - 2011/12
N2 - Objective: To determine if selected pro-inflammatory and anti-inflammatory cytokines and/or mediators of inflammation reported to be related to the development of cerebral palsy (CP) predict neurodevelopmental outcome in extremely low birth weight infants. Study design: Infants with birth weights ≤1000 g (n = 1067) had blood samples collected at birth and on days 3 ± 1, 7 ± 1, 14 ± 3, and 21 ± 3 to examine the association between cytokines and neurodevelopmental outcomes. The analyses were focused on 5 cytokines (interleukin [IL] 1β; IL-8; tumor necrosis factor-α; regulated upon activation, normal T-cell expressed, and secreted (RANTES); and IL-2) reported to be most predictive of CP in term and late preterm infants. Results: IL-8 was higher on days 0-4 and subsequently in infants who developed CP compared with infants who did not develop CP in both unadjusted and adjusted analyses. Other cytokines (IL-12, IL-17, tumor necrosis factor-β, soluble IL rα, macrophage inflammatory protein 1β) were found to be altered on days 0-4 in infants who developed CP. Conclusions: CP in former preterm infants may, in part, have a late perinatal and/or early neonatal inflammatory origin.
AB - Objective: To determine if selected pro-inflammatory and anti-inflammatory cytokines and/or mediators of inflammation reported to be related to the development of cerebral palsy (CP) predict neurodevelopmental outcome in extremely low birth weight infants. Study design: Infants with birth weights ≤1000 g (n = 1067) had blood samples collected at birth and on days 3 ± 1, 7 ± 1, 14 ± 3, and 21 ± 3 to examine the association between cytokines and neurodevelopmental outcomes. The analyses were focused on 5 cytokines (interleukin [IL] 1β; IL-8; tumor necrosis factor-α; regulated upon activation, normal T-cell expressed, and secreted (RANTES); and IL-2) reported to be most predictive of CP in term and late preterm infants. Results: IL-8 was higher on days 0-4 and subsequently in infants who developed CP compared with infants who did not develop CP in both unadjusted and adjusted analyses. Other cytokines (IL-12, IL-17, tumor necrosis factor-β, soluble IL rα, macrophage inflammatory protein 1β) were found to be altered on days 0-4 in infants who developed CP. Conclusions: CP in former preterm infants may, in part, have a late perinatal and/or early neonatal inflammatory origin.
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U2 - 10.1016/j.jpeds.2011.05.042
DO - 10.1016/j.jpeds.2011.05.042
M3 - Article
C2 - 21798559
AN - SCOPUS:80755128216
VL - 159
SP - 919-925.e3
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 6
ER -