TY - JOUR
T1 - Cytokines and neurodevelopmental outcomes in extremely low birth weight infants
AU - Carlo, Waldemar A.
AU - McDonald, Scott A.
AU - Tyson, Jon E.
AU - Stoll, Barbara J.
AU - Ehrenkranz, Richard A.
AU - Shankaran, Seetha
AU - Goldberg, Ronald N.
AU - Das, Abhik
AU - Schendel, Diana
AU - Thorsen, Poul
AU - Skogstrand, Kristin
AU - Hougaard, David M.
AU - Oh, William
AU - Laptook, Abbot R.
AU - Duara, Shahnaz
AU - Fanaroff, Avroy A.
AU - Donovan, Edward F.
AU - Korones, Sheldon B.
AU - Stevenson, David K.
AU - Papile, Lu Ann
AU - Finer, Neil N.
AU - O'Shea, T. Michael
AU - Poindexter, Brenda B.
AU - Wright, Linda L.
AU - Ambalavanan, Namasivayam
AU - Higgins, Rosemary D.
PY - 2011/12
Y1 - 2011/12
N2 - Objective: To determine if selected pro-inflammatory and anti-inflammatory cytokines and/or mediators of inflammation reported to be related to the development of cerebral palsy (CP) predict neurodevelopmental outcome in extremely low birth weight infants. Study design: Infants with birth weights ≤1000 g (n = 1067) had blood samples collected at birth and on days 3 ± 1, 7 ± 1, 14 ± 3, and 21 ± 3 to examine the association between cytokines and neurodevelopmental outcomes. The analyses were focused on 5 cytokines (interleukin [IL] 1β; IL-8; tumor necrosis factor-α; regulated upon activation, normal T-cell expressed, and secreted (RANTES); and IL-2) reported to be most predictive of CP in term and late preterm infants. Results: IL-8 was higher on days 0-4 and subsequently in infants who developed CP compared with infants who did not develop CP in both unadjusted and adjusted analyses. Other cytokines (IL-12, IL-17, tumor necrosis factor-β, soluble IL rα, macrophage inflammatory protein 1β) were found to be altered on days 0-4 in infants who developed CP. Conclusions: CP in former preterm infants may, in part, have a late perinatal and/or early neonatal inflammatory origin.
AB - Objective: To determine if selected pro-inflammatory and anti-inflammatory cytokines and/or mediators of inflammation reported to be related to the development of cerebral palsy (CP) predict neurodevelopmental outcome in extremely low birth weight infants. Study design: Infants with birth weights ≤1000 g (n = 1067) had blood samples collected at birth and on days 3 ± 1, 7 ± 1, 14 ± 3, and 21 ± 3 to examine the association between cytokines and neurodevelopmental outcomes. The analyses were focused on 5 cytokines (interleukin [IL] 1β; IL-8; tumor necrosis factor-α; regulated upon activation, normal T-cell expressed, and secreted (RANTES); and IL-2) reported to be most predictive of CP in term and late preterm infants. Results: IL-8 was higher on days 0-4 and subsequently in infants who developed CP compared with infants who did not develop CP in both unadjusted and adjusted analyses. Other cytokines (IL-12, IL-17, tumor necrosis factor-β, soluble IL rα, macrophage inflammatory protein 1β) were found to be altered on days 0-4 in infants who developed CP. Conclusions: CP in former preterm infants may, in part, have a late perinatal and/or early neonatal inflammatory origin.
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U2 - 10.1016/j.jpeds.2011.05.042
DO - 10.1016/j.jpeds.2011.05.042
M3 - Article
C2 - 21798559
AN - SCOPUS:80755128216
VL - 159
SP - 919-925.e3
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 6
ER -