Cytokine response in children undergoing surgery for congenital heart disease

Ashish B. Madhok, Kaie Ojamaa, Viraga Haridas, Vincent A. Parnell, Savita G Pahwa, D. Chowdhury

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Pediatric cardiac surgery with cardiopulmonary bypass (CPB) induces a complex inflammatory response that may cause multiorgan dysfunction. The objective of this study was to measure postoperative cytokine production and correlate the magnitude of this response with intraoperative variables and postoperative outcomes. Serum samples from 20 children (median age, 15 months) undergoing cardiac surgery with CPB were obtained preoperatively and on postoperative days (POD) 1-3. Serum levels of interleukin (IL)-6, IL-8, and IL-10 increased significantly on POD 1 (p < 0.01) vs pre-op values to 271 ± 68, 44 ± 9, 7.5 ± 0.8 pg/ml, respectively, whereas serum IL-1β, IL-12, and tumor neurosis factor -α were not significantly changed. The serum IL-6 and IL-8 levels correlated positively (p < 0.01) with the degree of postoperative medical intervention as measured by the Therapeutic Interventional Scoring System and indicated a greater need for inotropic support (p = 0.057). A negative correlation (p < 0.01) between IL-6, IL-8, and mixed venous oxygen saturation suggested compromised cardiopulmonary function. Patients with single ventricle anatomy had the highest levels of IL-6 and IL-8 (629 ± 131 and 70 ± 17 pg/ml, respectively), with a mean CPB time of 106 ± 23 minutes. Thus, the proinflammatory response after surgery with CPB was associated with postoperative morbidity with increased need for medical intervention.

Original languageEnglish
Pages (from-to)408-413
Number of pages6
JournalPediatric Cardiology
Volume27
Issue number4
DOIs
StatePublished - Aug 1 2006
Externally publishedYes

Fingerprint

Cardiopulmonary Bypass
Interleukin-8
Heart Diseases
Interleukin-6
Cytokines
Serum
Thoracic Surgery
Neurotic Disorders
Interleukin-12
Interleukin-1
Interleukin-10
Anatomy
Pediatrics
Oxygen
Morbidity
Neoplasms
Therapeutics

Keywords

  • Cardiopulmonary bypass
  • Cytokines
  • Inotropes
  • Interleukin
  • TISS

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

Cytokine response in children undergoing surgery for congenital heart disease. / Madhok, Ashish B.; Ojamaa, Kaie; Haridas, Viraga; Parnell, Vincent A.; Pahwa, Savita G; Chowdhury, D.

In: Pediatric Cardiology, Vol. 27, No. 4, 01.08.2006, p. 408-413.

Research output: Contribution to journalArticle

Madhok, AB, Ojamaa, K, Haridas, V, Parnell, VA, Pahwa, SG & Chowdhury, D 2006, 'Cytokine response in children undergoing surgery for congenital heart disease', Pediatric Cardiology, vol. 27, no. 4, pp. 408-413. https://doi.org/10.1007/s00246-006-0934-y
Madhok, Ashish B. ; Ojamaa, Kaie ; Haridas, Viraga ; Parnell, Vincent A. ; Pahwa, Savita G ; Chowdhury, D. / Cytokine response in children undergoing surgery for congenital heart disease. In: Pediatric Cardiology. 2006 ; Vol. 27, No. 4. pp. 408-413.
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