Abstract
Mammary tumor development has multiple effects on the T cell, B cell, and macrophage compartments of the hosts as evidenced by the alterations in their phenotype and functions. Cytokines are known to modulate the immune system, thus a study of the production of these factors has great relevance to tumor immunity. Here we present evidence that tumor progression causes a profound dysregulation of the cytokine production by various lymphoreticular cells. Furthermore, the tumors themselves are capable of secreting factors that can directly or indirectly affect the cells of the immune system, thereby resulting in the immunosuppressive and other deleterious effects that favor the progress of the neoplastic disease.
| Original language | English |
|---|---|
| Pages (from-to) | 3923-3929 |
| Number of pages | 7 |
| Journal | Anticancer Research |
| Volume | 16 |
| Issue number | 6 C |
| State | Published - Dec 1 1996 |
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Keywords
- Cytokines
- Mammary tumors
- Tumor-derived factors
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Cytokine production by lymphoreticular cells from mammary tumor bearing mice : The role of tumor-derived factors. / Lopez, Diana M; Handel-Fernandez, M. E.; Cheng, X.; Charyulu, V.; Herbert, L. M.; Dinapoli, M. R.; Calderon, C. L.
In: Anticancer Research, Vol. 16, No. 6 C, 01.12.1996, p. 3923-3929.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cytokine production by lymphoreticular cells from mammary tumor bearing mice
T2 - The role of tumor-derived factors
AU - Lopez, Diana M
AU - Handel-Fernandez, M. E.
AU - Cheng, X.
AU - Charyulu, V.
AU - Herbert, L. M.
AU - Dinapoli, M. R.
AU - Calderon, C. L.
PY - 1996/12/1
Y1 - 1996/12/1
N2 - Mammary tumor development has multiple effects on the T cell, B cell, and macrophage compartments of the hosts as evidenced by the alterations in their phenotype and functions. Cytokines are known to modulate the immune system, thus a study of the production of these factors has great relevance to tumor immunity. Here we present evidence that tumor progression causes a profound dysregulation of the cytokine production by various lymphoreticular cells. Furthermore, the tumors themselves are capable of secreting factors that can directly or indirectly affect the cells of the immune system, thereby resulting in the immunosuppressive and other deleterious effects that favor the progress of the neoplastic disease.
AB - Mammary tumor development has multiple effects on the T cell, B cell, and macrophage compartments of the hosts as evidenced by the alterations in their phenotype and functions. Cytokines are known to modulate the immune system, thus a study of the production of these factors has great relevance to tumor immunity. Here we present evidence that tumor progression causes a profound dysregulation of the cytokine production by various lymphoreticular cells. Furthermore, the tumors themselves are capable of secreting factors that can directly or indirectly affect the cells of the immune system, thereby resulting in the immunosuppressive and other deleterious effects that favor the progress of the neoplastic disease.
KW - Cytokines
KW - Mammary tumors
KW - Tumor-derived factors
UR - http://www.scopus.com/inward/record.url?scp=0030515965&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030515965&partnerID=8YFLogxK
M3 - Article
VL - 16
SP - 3923
EP - 3929
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 6 C
ER -