Cytokine production by lymphoreticular cells from mammary tumor bearing mice

The role of tumor-derived factors

Diana M Lopez, M. E. Handel-Fernandez, X. Cheng, V. Charyulu, L. M. Herbert, M. R. Dinapoli, C. L. Calderon

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Mammary tumor development has multiple effects on the T cell, B cell, and macrophage compartments of the hosts as evidenced by the alterations in their phenotype and functions. Cytokines are known to modulate the immune system, thus a study of the production of these factors has great relevance to tumor immunity. Here we present evidence that tumor progression causes a profound dysregulation of the cytokine production by various lymphoreticular cells. Furthermore, the tumors themselves are capable of secreting factors that can directly or indirectly affect the cells of the immune system, thereby resulting in the immunosuppressive and other deleterious effects that favor the progress of the neoplastic disease.

Original languageEnglish
Pages (from-to)3923-3929
Number of pages7
JournalAnticancer Research
Volume16
Issue number6 C
StatePublished - Dec 1 1996

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Breast Neoplasms
Cytokines
Immune System
Neoplasms
Immunosuppressive Agents
Immunity
B-Lymphocytes
Macrophages
T-Lymphocytes
Phenotype

Keywords

  • Cytokines
  • Mammary tumors
  • Tumor-derived factors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Lopez, D. M., Handel-Fernandez, M. E., Cheng, X., Charyulu, V., Herbert, L. M., Dinapoli, M. R., & Calderon, C. L. (1996). Cytokine production by lymphoreticular cells from mammary tumor bearing mice: The role of tumor-derived factors. Anticancer Research, 16(6 C), 3923-3929.

Cytokine production by lymphoreticular cells from mammary tumor bearing mice : The role of tumor-derived factors. / Lopez, Diana M; Handel-Fernandez, M. E.; Cheng, X.; Charyulu, V.; Herbert, L. M.; Dinapoli, M. R.; Calderon, C. L.

In: Anticancer Research, Vol. 16, No. 6 C, 01.12.1996, p. 3923-3929.

Research output: Contribution to journalArticle

Lopez, DM, Handel-Fernandez, ME, Cheng, X, Charyulu, V, Herbert, LM, Dinapoli, MR & Calderon, CL 1996, 'Cytokine production by lymphoreticular cells from mammary tumor bearing mice: The role of tumor-derived factors', Anticancer Research, vol. 16, no. 6 C, pp. 3923-3929.
Lopez DM, Handel-Fernandez ME, Cheng X, Charyulu V, Herbert LM, Dinapoli MR et al. Cytokine production by lymphoreticular cells from mammary tumor bearing mice: The role of tumor-derived factors. Anticancer Research. 1996 Dec 1;16(6 C):3923-3929.
Lopez, Diana M ; Handel-Fernandez, M. E. ; Cheng, X. ; Charyulu, V. ; Herbert, L. M. ; Dinapoli, M. R. ; Calderon, C. L. / Cytokine production by lymphoreticular cells from mammary tumor bearing mice : The role of tumor-derived factors. In: Anticancer Research. 1996 ; Vol. 16, No. 6 C. pp. 3923-3929.
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