Cytokine production by lymphoreticular cells from mammary tumor bearing mice: the role of tumor-derived factors

Diana M. Lopez, Mary E. Handel-Fernandez, Xiaofang Cheng, Vijaya Charyulu, Lynn M. Herbert, Michael R. Dinapoli, Cesar L. Calderon

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Mammary tumor development has multiple effects on the T cell, B cell, and macrophage compartments of the hosts as evidenced by the alterations in their phenotype and functions. Cytokines are known to modulate the immune system, thus a study of the production of these factors has great relevance to tumor immunity. Here we present evidence that tumor progression causes a profound dysregulation of the cytokine production by various lymphoreticular cells. Furthermore, the tumors themselves are capable of secreting factors that can directly or indirectly affect the cells of the immune system, thereby resulting in the immunosuppressive and other deleterious effects that favor the progress of the neoplastic disease.

Original languageEnglish (US)
Pages (from-to)3923-3930
Number of pages8
JournalAnticancer research
Volume16
Issue number6 C
StatePublished - Dec 1 1996

Keywords

  • Cytokines
  • Mammary tumors
  • Tumor-derived factors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Lopez, D. M., Handel-Fernandez, M. E., Cheng, X., Charyulu, V., Herbert, L. M., Dinapoli, M. R., & Calderon, C. L. (1996). Cytokine production by lymphoreticular cells from mammary tumor bearing mice: the role of tumor-derived factors. Anticancer research, 16(6 C), 3923-3930.