Cytokine genetic polymorphisms and prostate cancer aggressiveness

Jovanny Zabaleta, L. Joseph Su, Hui Yi Lin, Rosa A. Sierra, M. Craig Hall, A. Oliver Sartor, Peter E. Clark, Jennifer Hu, Augusto C. Ochoa

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Abstract

Prostate cancer (PCa) is one of the most common cancers in the world. Inflammation has been described as a risk factor for PCa and depends on the production of cytokines in response to tissue damage or the presence of stimuli that induces cellular stress. Interindividual variation in cytokine production is partially controlled by single-nucleotide polymorphisms (SNPs) that have been associated with differential production of cytokines. We have recently showed that SNP-SNP interactions of cytokine genes are associated with PCa risk. However, little is known about the association of cytokine SNPs and PCa aggressiveness. In this study, we evaluated the association of 15 SNPs in five cytokine genes and aggressiveness of PCa in African- and Caucasian-American individuals. Caucasian Americans with the genotypes IL10-1082GG or IL1B=3954TT had 2.31-fold [95% confidence interval (CI) = 1.13-4.72] and 3.11 (95% CI = 1.20-8.06)-fold risk, respectively, of developing aggressive PCa, as compared with individuals without those genotypes. We did not find any associations in the African-American group. Using Multivariate Adaptive Regression Splines modeling for exploratory SNP-SNP interactions, our results showed that more aggressive PCa in Caucasians Americans is associated with the CT genotype at IL8-47 [odds ratios (OR) = 3.50; 95% CI = 1.13-10.88] or combined genotypes of IL1B-511CC and IL10-1082GG (OR = 3.38; 95% CI = 1.70 - 6.71). Unfortunately, the same analysis could not be performed in the African-Americans due to limited number of individuals. With limited sample size, the results from this study suggest that SNPs in cytokine genes may be associated with PCa aggressiveness. More extensive studies are warranted to validate our findings.

Original languageEnglish
Pages (from-to)1358-1362
Number of pages5
JournalCarcinogenesis
Volume30
Issue number8
DOIs
StatePublished - Oct 1 2009

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Genetic Polymorphisms
Single Nucleotide Polymorphism
Cytokines
Prostatic Neoplasms
Genotype
African Americans
Confidence Intervals
Interleukin-10
Odds Ratio
Genes
Prostate Cancer, Hereditary, 7
Interleukin-8
Sample Size
Inflammation

ASJC Scopus subject areas

  • Cancer Research

Cite this

Zabaleta, J., Su, L. J., Lin, H. Y., Sierra, R. A., Hall, M. C., Sartor, A. O., ... Ochoa, A. C. (2009). Cytokine genetic polymorphisms and prostate cancer aggressiveness. Carcinogenesis, 30(8), 1358-1362. https://doi.org/10.1093/carcin/bgp124

Cytokine genetic polymorphisms and prostate cancer aggressiveness. / Zabaleta, Jovanny; Su, L. Joseph; Lin, Hui Yi; Sierra, Rosa A.; Hall, M. Craig; Sartor, A. Oliver; Clark, Peter E.; Hu, Jennifer; Ochoa, Augusto C.

In: Carcinogenesis, Vol. 30, No. 8, 01.10.2009, p. 1358-1362.

Research output: Contribution to journalArticle

Zabaleta, J, Su, LJ, Lin, HY, Sierra, RA, Hall, MC, Sartor, AO, Clark, PE, Hu, J & Ochoa, AC 2009, 'Cytokine genetic polymorphisms and prostate cancer aggressiveness', Carcinogenesis, vol. 30, no. 8, pp. 1358-1362. https://doi.org/10.1093/carcin/bgp124
Zabaleta J, Su LJ, Lin HY, Sierra RA, Hall MC, Sartor AO et al. Cytokine genetic polymorphisms and prostate cancer aggressiveness. Carcinogenesis. 2009 Oct 1;30(8):1358-1362. https://doi.org/10.1093/carcin/bgp124
Zabaleta, Jovanny ; Su, L. Joseph ; Lin, Hui Yi ; Sierra, Rosa A. ; Hall, M. Craig ; Sartor, A. Oliver ; Clark, Peter E. ; Hu, Jennifer ; Ochoa, Augusto C. / Cytokine genetic polymorphisms and prostate cancer aggressiveness. In: Carcinogenesis. 2009 ; Vol. 30, No. 8. pp. 1358-1362.
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