Cytogenetic evidence that a tumor suppressor gene in the long arm of chromosome 1 contributes to glioma growth

You S. Li; David A. Ramsay; Yao Shan Fan; Ross F. Armstrong; Rolando F. Del Maestro

doi:10.1016/0165-4608(95)00065-8

Cytogenetic evidence that a tumor suppressor gene in the long arm of chromosome 1 contributes to glioma growth

You S. Li, David A. Ramsay, Yao Shan Fan, Ross F. Armstrong, Rolando F. Del Maestro

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

In a patient with a rare subtype of glioma, pleomorphic xanthoastrocytoma, cytogenetic studies revealed that both homologues of chromosome 1 were involved in translocations at the same band 1q42 but with different partner chromosomes. In addition, 5 glioblastomas out of 25 gliomas karyotyped in our laboratory had lost at least one copy of band 1q42 through deletions, unbalanced rearrangements, or chromosome losses. Twenty-one gliomas that had lost at least one copy of chromosome band 1q42 were identified in the literature; all were astrocytic tumors and the majority were glioblastomas. It indicates a covert tumor suppressor gene in the region that is involved in astrocytic gliomas.

Original language	English (US)
Pages (from-to)	46-50
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	84
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(95)00065-8
State	Published - Oct 1 1995
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

Access to Document

10.1016/0165-4608(95)00065-8

Fingerprint Dive into the research topics of 'Cytogenetic evidence that a tumor suppressor gene in the long arm of chromosome 1 contributes to glioma growth'. Together they form a unique fingerprint.

Cite this

@article{02c5f7cfafa54a39994966675febc8da,

title = "Cytogenetic evidence that a tumor suppressor gene in the long arm of chromosome 1 contributes to glioma growth",

abstract = "In a patient with a rare subtype of glioma, pleomorphic xanthoastrocytoma, cytogenetic studies revealed that both homologues of chromosome 1 were involved in translocations at the same band 1q42 but with different partner chromosomes. In addition, 5 glioblastomas out of 25 gliomas karyotyped in our laboratory had lost at least one copy of band 1q42 through deletions, unbalanced rearrangements, or chromosome losses. Twenty-one gliomas that had lost at least one copy of chromosome band 1q42 were identified in the literature; all were astrocytic tumors and the majority were glioblastomas. It indicates a covert tumor suppressor gene in the region that is involved in astrocytic gliomas.",

author = "Li, {You S.} and Ramsay, {David A.} and Fan, {Yao Shan} and Armstrong, {Ross F.} and {Del Maestro}, {Rolando F.}",

year = "1995",

month = oct,

day = "1",

doi = "10.1016/0165-4608(95)00065-8",

language = "English (US)",

volume = "84",

pages = "46--50",

journal = "Cancer Genetics and Cytogenetics",

issn = "0165-4608",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - Cytogenetic evidence that a tumor suppressor gene in the long arm of chromosome 1 contributes to glioma growth

AU - Li, You S.

AU - Ramsay, David A.

AU - Fan, Yao Shan

AU - Armstrong, Ross F.

AU - Del Maestro, Rolando F.

PY - 1995/10/1

Y1 - 1995/10/1

N2 - In a patient with a rare subtype of glioma, pleomorphic xanthoastrocytoma, cytogenetic studies revealed that both homologues of chromosome 1 were involved in translocations at the same band 1q42 but with different partner chromosomes. In addition, 5 glioblastomas out of 25 gliomas karyotyped in our laboratory had lost at least one copy of band 1q42 through deletions, unbalanced rearrangements, or chromosome losses. Twenty-one gliomas that had lost at least one copy of chromosome band 1q42 were identified in the literature; all were astrocytic tumors and the majority were glioblastomas. It indicates a covert tumor suppressor gene in the region that is involved in astrocytic gliomas.

AB - In a patient with a rare subtype of glioma, pleomorphic xanthoastrocytoma, cytogenetic studies revealed that both homologues of chromosome 1 were involved in translocations at the same band 1q42 but with different partner chromosomes. In addition, 5 glioblastomas out of 25 gliomas karyotyped in our laboratory had lost at least one copy of band 1q42 through deletions, unbalanced rearrangements, or chromosome losses. Twenty-one gliomas that had lost at least one copy of chromosome band 1q42 were identified in the literature; all were astrocytic tumors and the majority were glioblastomas. It indicates a covert tumor suppressor gene in the region that is involved in astrocytic gliomas.

UR - http://www.scopus.com/inward/record.url?scp=0028840592&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028840592&partnerID=8YFLogxK

U2 - 10.1016/0165-4608(95)00065-8

DO - 10.1016/0165-4608(95)00065-8

M3 - Article

C2 - 7497442

AN - SCOPUS:0028840592

VL - 84

SP - 46

EP - 50

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

SN - 0165-4608

IS - 1

ER -

Cytogenetic evidence that a tumor suppressor gene in the long arm of chromosome 1 contributes to glioma growth

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Cite this