TY - JOUR
T1 - Cytogenetic evidence that a tumor suppressor gene in the long arm of chromosome 1 contributes to glioma growth
AU - Li, You S.
AU - Ramsay, David A.
AU - Fan, Yao Shan
AU - Armstrong, Ross F.
AU - Del Maestro, Rolando F.
PY - 1995/10/1
Y1 - 1995/10/1
N2 - In a patient with a rare subtype of glioma, pleomorphic xanthoastrocytoma, cytogenetic studies revealed that both homologues of chromosome 1 were involved in translocations at the same band 1q42 but with different partner chromosomes. In addition, 5 glioblastomas out of 25 gliomas karyotyped in our laboratory had lost at least one copy of band 1q42 through deletions, unbalanced rearrangements, or chromosome losses. Twenty-one gliomas that had lost at least one copy of chromosome band 1q42 were identified in the literature; all were astrocytic tumors and the majority were glioblastomas. It indicates a covert tumor suppressor gene in the region that is involved in astrocytic gliomas.
AB - In a patient with a rare subtype of glioma, pleomorphic xanthoastrocytoma, cytogenetic studies revealed that both homologues of chromosome 1 were involved in translocations at the same band 1q42 but with different partner chromosomes. In addition, 5 glioblastomas out of 25 gliomas karyotyped in our laboratory had lost at least one copy of band 1q42 through deletions, unbalanced rearrangements, or chromosome losses. Twenty-one gliomas that had lost at least one copy of chromosome band 1q42 were identified in the literature; all were astrocytic tumors and the majority were glioblastomas. It indicates a covert tumor suppressor gene in the region that is involved in astrocytic gliomas.
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U2 - 10.1016/0165-4608(95)00065-8
DO - 10.1016/0165-4608(95)00065-8
M3 - Article
C2 - 7497442
AN - SCOPUS:0028840592
VL - 84
SP - 46
EP - 50
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 1
ER -