Cytofluorographic and molecular identification of a CD8-positive, TCR-α/β-negative intraocular T cell lymphoma: A case report and review of the literature

Alvaro D. Saenz, Alexandra Amador, Brianna M. Ruiz, Janet Davis, Phillip Ruiz

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Introduction: Cytofluorographic and molecular techniques are effective adjuncts in diagnosing intraocular lymphoma. Primary intraocular lymphoma is an uncommon entity predominantly of B cell origin and rarely with a T cell phenotype. The aim of the present paper is to report a case of a CD8-positive, TCR-α/β-negative intraocular T cell lymphoma and review the literature. Case presentation: T cell neoplasia was detected based on flow cytometric demonstration of an abnormal T cell population and polymerase chain reactions for immunoglobulin and T-cell receptor rearrangements demonstrating evidence of monoclonality. Flow cytometry revealed a T cell population aberrantly expressing T-cell lineage markers. This T cell population expressed CD2, bright CD3, CD8, bright CD7, CD38, CD69, and variable CD25. T-cell receptor γ gene rearrangement studies demonstrated evidence of T-cell gene rearrangement confirming that the T cells were monoclonal. Conclusion: We herein report the rare case of aTCR α/β- negative CD8+ intraocular T-cell lymphoma suggestive of gamma/delta origin diagnosed by flow cytometry and polymerase chain reaction.

Original languageEnglish (US)
Article number114
JournalJournal of medical case reports
Volume1
DOIs
StatePublished - Jun 2 2007

ASJC Scopus subject areas

  • Medicine(all)

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