Cytochalasin-B: Time-lapse cinematographic studies on its effects on cytokinesis

Awtar Krishan

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


L cells exposed to cytochalasin-B (cvto-B) show the normal development of deep cleavage furrows in both bipolar and multipolar cell divisions Due to the drug-induced inhibition of cellular motility, the resulting daughter cells do not move away from each other but reunite to form multinucleate cells. In mitotic cells from cultures exposed to cyto-B for long periods of time, vigorous blebbing and contraction of the cell surface is seen The evidence from time-lapse studies presented suggests that cyto-B-induced multinucleate cells are formed, not by the failure of the cleavage furrow, but by the drug-induced changes in surface activity and motility of cells after division.

Original languageEnglish (US)
Pages (from-to)657-664
Number of pages8
JournalJournal of Cell Biology
Issue number3
StatePublished - Sep 1 1972
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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