TY - JOUR
T1 - CYP2D6 Poor Metabolizer Genotype and Smoking Predict Severe Postoperative Pain in Female Patients on Arrival to the Recovery Room
AU - Yang, Zongqi
AU - Yang, Zhe
AU - Arheart, Kristopher L.
AU - Morris, Richard
AU - Zhang, Yanping
AU - Rodriguez, Yiliam
AU - Song, Chunyu
AU - Gitlin, Melvin C.
AU - Candiotti, Keith A.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2012/4
Y1 - 2012/4
N2 - Recent studies have shown that CYP2D6 acts at critical steps for endogenous morphine biosynthesis. The present study assessed the contribution of CYP2D6 genetic polymorphisms, smoking, and other factors on acute severe postoperative pain (linear analog pain scores ≥8). Methods. Two hundred thirty-six female patients were found to have adequate information in a previously developed female surgical patient database to be included in this current analysis. Multiple logistic regression analysis was used to assess the predictors for acute severe postoperative pain. DNA had been previously extracted from blood samples in all patients and was genotyped by the Amplichip to determine the specific CYP2D6 genotypes. Results. It was noted that the incidence of acute severe postoperative pain (linear analog pain scores ≥8) was more frequent in patients with the CYP2D6 poor metabolizer (PM) genotype, 71%, compared with 28% in intermediate metabolizers (IMs), 26% in extensive metabolizers (EMs), and 27% in ultrarapid metabolizers (UMs). The overall association between metabolizer groups and severe postoperative pain was significant (P=0.023). PMs were significantly more likely to suffer from severe postoperative pain than IMs, EMs, and UMs (P=0.007, 0.002, and 0.050, respectively). There were no significant differences among IMs, EMs, and UMs. Additionally, it was noted that there was an increased frequency of acute severe postoperative pain in smokers vs nonsmokers (P=0.014). Conclusion. This study demonstrated that female patients possessing the PM genotype of CYP2D6 and patients who smoke had a higher incidence of acute severe postoperative pain. Wiley Periodicals, Inc..
AB - Recent studies have shown that CYP2D6 acts at critical steps for endogenous morphine biosynthesis. The present study assessed the contribution of CYP2D6 genetic polymorphisms, smoking, and other factors on acute severe postoperative pain (linear analog pain scores ≥8). Methods. Two hundred thirty-six female patients were found to have adequate information in a previously developed female surgical patient database to be included in this current analysis. Multiple logistic regression analysis was used to assess the predictors for acute severe postoperative pain. DNA had been previously extracted from blood samples in all patients and was genotyped by the Amplichip to determine the specific CYP2D6 genotypes. Results. It was noted that the incidence of acute severe postoperative pain (linear analog pain scores ≥8) was more frequent in patients with the CYP2D6 poor metabolizer (PM) genotype, 71%, compared with 28% in intermediate metabolizers (IMs), 26% in extensive metabolizers (EMs), and 27% in ultrarapid metabolizers (UMs). The overall association between metabolizer groups and severe postoperative pain was significant (P=0.023). PMs were significantly more likely to suffer from severe postoperative pain than IMs, EMs, and UMs (P=0.007, 0.002, and 0.050, respectively). There were no significant differences among IMs, EMs, and UMs. Additionally, it was noted that there was an increased frequency of acute severe postoperative pain in smokers vs nonsmokers (P=0.014). Conclusion. This study demonstrated that female patients possessing the PM genotype of CYP2D6 and patients who smoke had a higher incidence of acute severe postoperative pain. Wiley Periodicals, Inc..
KW - Genotype
KW - Metabolizer
KW - Pain
UR - http://www.scopus.com/inward/record.url?scp=84859781049&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859781049&partnerID=8YFLogxK
U2 - 10.1111/j.1526-4637.2012.01296.x
DO - 10.1111/j.1526-4637.2012.01296.x
M3 - Article
C2 - 22497725
AN - SCOPUS:84859781049
VL - 13
SP - 604
EP - 609
JO - Pain Medicine
JF - Pain Medicine
SN - 1526-2375
IS - 4
ER -