Cyclosporine increases muscular force generation in Duchenne muscular dystrophy

Khema R Sharma, Mark A. Mynhier, Robert G. Miller

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

We investigated the effect of cyclosporine (CsA) on force generation in 15 boys with Duchenne muscular dystrophy (DMD) by obtaining monthly measures of tetanic force and maximum voluntary contraction (MVC) of both anterior tibial muscles. During 4 months of a natural history phase, both tetanic force and MVC declined significantly. During 8 weeks of CsA treatment (5 mg/kg/day), significantly increased tetanic force (25.8 ± 6.6%) and MVC (13.6 ± 4.0%) occurred within 2 weeks. The maximum mean increase during treatment was 35.2 ± 5.9% (tetanic force) and 19.0 ± 4.6% (MVC). Side effects from CsA, gastrointestinal and flu-like symptoms, were transient and self-limiting. Thus, as previously reported with prednisone, CsA increases muscular force generation in the anterior tibial muscles of DMD patients.

Original languageEnglish
Pages (from-to)527-532
Number of pages6
JournalNeurology
Volume43
Issue number3
StatePublished - Mar 1 1993
Externally publishedYes

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Duchenne Muscular Dystrophy
Cyclosporine
Skeletal Muscle
Prednisone
Natural History
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cyclosporine increases muscular force generation in Duchenne muscular dystrophy. / Sharma, Khema R; Mynhier, Mark A.; Miller, Robert G.

In: Neurology, Vol. 43, No. 3, 01.03.1993, p. 527-532.

Research output: Contribution to journalArticle

Sharma, KR, Mynhier, MA & Miller, RG 1993, 'Cyclosporine increases muscular force generation in Duchenne muscular dystrophy', Neurology, vol. 43, no. 3, pp. 527-532.
Sharma, Khema R ; Mynhier, Mark A. ; Miller, Robert G. / Cyclosporine increases muscular force generation in Duchenne muscular dystrophy. In: Neurology. 1993 ; Vol. 43, No. 3. pp. 527-532.
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