Cyclosporine A decreases kallikrein and BK2 mRNA expression in the rat renal cortex

Guy Bompart, Ivan Tack, Encarna Marin Castaño, João Bosco Pesquero, Jean Pierre Girolami, Jean Loup Bascands

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The effect of subcutaneous injection of cyclosporine (20 mg/kg/day for 3 days) on the expression of kallikrein (Kal) and bradykinin 2 receptor (BK2) mRNA in the rat renal cortex was examined. CsA decreased significantly Kal and BK2 mRNA expression in the kidney cortex. These results indicate that the kallikrein-kinin system may participate in the genesis or the aggravation of the renal haemodynamic effect induced by long term administration of CsA.

Original languageEnglish (US)
Pages (from-to)99-101
Number of pages3
JournalImmunopharmacology
Volume32
Issue number1-3
DOIs
StatePublished - May 1996

Keywords

  • Bradykinin B2 receptor
  • Cyclosporine A
  • Kallikrein
  • Kidney
  • mRNA

ASJC Scopus subject areas

  • Pharmacology

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    Bompart, G., Tack, I., Castaño, E. M., Pesquero, J. B., Girolami, J. P., & Bascands, J. L. (1996). Cyclosporine A decreases kallikrein and BK2 mRNA expression in the rat renal cortex. Immunopharmacology, 32(1-3), 99-101. https://doi.org/10.1016/0162-3109(95)00063-1