Cyclosporine A decreases kallikrein and BK2 mRNA expression in the rat renal cortex

Guy Bompart, Ivan Tack, Encarna Marin Castaño, João Bosco Pesquero, Jean Pierre Girolami, Jean Loup Bascands

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effect of subcutaneous injection of cyclosporine (20 mg/kg/day for 3 days) on the expression of kallikrein (Kal) and bradykinin 2 receptor (BK2) mRNA in the rat renal cortex was examined. CsA decreased significantly Kal and BK2 mRNA expression in the kidney cortex. These results indicate that the kallikrein-kinin system may participate in the genesis or the aggravation of the renal haemodynamic effect induced by long term administration of CsA.

Original languageEnglish
Pages (from-to)99-101
Number of pages3
JournalImmunopharmacology
Volume32
Issue number1-3
DOIs
StatePublished - May 1 1996
Externally publishedYes

Fingerprint

Bradykinin Receptors
Tissue Kallikreins
Cyclosporine
Kallikrein-Kinin System
Kidney
Kidney Cortex
Messenger RNA
Subcutaneous Injections
Hemodynamics

Keywords

  • Bradykinin B2 receptor
  • Cyclosporine A
  • Kallikrein
  • Kidney
  • mRNA

ASJC Scopus subject areas

  • Pharmacology

Cite this

Bompart, G., Tack, I., Castaño, E. M., Pesquero, J. B., Girolami, J. P., & Bascands, J. L. (1996). Cyclosporine A decreases kallikrein and BK2 mRNA expression in the rat renal cortex. Immunopharmacology, 32(1-3), 99-101. https://doi.org/10.1016/0162-3109(95)00063-1

Cyclosporine A decreases kallikrein and BK2 mRNA expression in the rat renal cortex. / Bompart, Guy; Tack, Ivan; Castaño, Encarna Marin; Pesquero, João Bosco; Girolami, Jean Pierre; Bascands, Jean Loup.

In: Immunopharmacology, Vol. 32, No. 1-3, 01.05.1996, p. 99-101.

Research output: Contribution to journalArticle

Bompart, G, Tack, I, Castaño, EM, Pesquero, JB, Girolami, JP & Bascands, JL 1996, 'Cyclosporine A decreases kallikrein and BK2 mRNA expression in the rat renal cortex', Immunopharmacology, vol. 32, no. 1-3, pp. 99-101. https://doi.org/10.1016/0162-3109(95)00063-1
Bompart G, Tack I, Castaño EM, Pesquero JB, Girolami JP, Bascands JL. Cyclosporine A decreases kallikrein and BK2 mRNA expression in the rat renal cortex. Immunopharmacology. 1996 May 1;32(1-3):99-101. https://doi.org/10.1016/0162-3109(95)00063-1
Bompart, Guy ; Tack, Ivan ; Castaño, Encarna Marin ; Pesquero, João Bosco ; Girolami, Jean Pierre ; Bascands, Jean Loup. / Cyclosporine A decreases kallikrein and BK2 mRNA expression in the rat renal cortex. In: Immunopharmacology. 1996 ; Vol. 32, No. 1-3. pp. 99-101.
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