Cyclophosphamide therapy of severe systemic necrotizing vasculitis

A. S. Fauci, P. Katz, B. F. Haynes, S. M. Wolff

Research output: Contribution to journalArticle

417 Citations (Scopus)

Abstract

The authors studied 17 patients with severe systemic necrotizing vasculitis over an 11-year-period. Sixteen patients were treated daily with cyclophosphamide (2 mg per kilogram per day), and one was treated with azathioprine (2 mg per kilogram per day). Before entering the study, all patients had active and progressive disease, even though 16 patients had been receiving corticosteroids that had caused severe and often incapacitating toxic side effects. Three patients died during the study. Complete and often dramatic remissions occurred in the surviving 14 patients, who were then placed on alternate-day corticosteroid treatment with continuation of cyclophosphamide. Corticosteroids were later discontinued in seven patients. The mean duration of remission was 22 months (range, two to 61). No patient showed recurrence of disease during treatment with cytotoxic agents.

Original languageEnglish
Pages (from-to)235-238
Number of pages4
JournalNew England Journal of Medicine
Volume301
Issue number5
StatePublished - Dec 1 1979
Externally publishedYes

Fingerprint

Systemic Vasculitis
Cyclophosphamide
Adrenal Cortex Hormones
Therapeutics
Poisons
Cytotoxins
Azathioprine
Recurrence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fauci, A. S., Katz, P., Haynes, B. F., & Wolff, S. M. (1979). Cyclophosphamide therapy of severe systemic necrotizing vasculitis. New England Journal of Medicine, 301(5), 235-238.

Cyclophosphamide therapy of severe systemic necrotizing vasculitis. / Fauci, A. S.; Katz, P.; Haynes, B. F.; Wolff, S. M.

In: New England Journal of Medicine, Vol. 301, No. 5, 01.12.1979, p. 235-238.

Research output: Contribution to journalArticle

Fauci, AS, Katz, P, Haynes, BF & Wolff, SM 1979, 'Cyclophosphamide therapy of severe systemic necrotizing vasculitis', New England Journal of Medicine, vol. 301, no. 5, pp. 235-238.
Fauci AS, Katz P, Haynes BF, Wolff SM. Cyclophosphamide therapy of severe systemic necrotizing vasculitis. New England Journal of Medicine. 1979 Dec 1;301(5):235-238.
Fauci, A. S. ; Katz, P. ; Haynes, B. F. ; Wolff, S. M. / Cyclophosphamide therapy of severe systemic necrotizing vasculitis. In: New England Journal of Medicine. 1979 ; Vol. 301, No. 5. pp. 235-238.
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