Cyclooxygenase-1 inhibition prolongs postnatal ovarian follicle lifespan in mice

Elizabeth R. Smith, Wan Lin Yang, Toni Yeasky, Jennifer Smedberg, Kathy Q. Cai, Xiangxi Xu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Menopause is the permanent cessation of menstruation that results from depletion of ovarian germ cells and follicles. Although most animals experience reproductive senescence, the mechanisms differ from that in women, who may live more than one-third of their lives after menopause and consequently face the risk of a number of menopause-associated health problems. Understanding factors that influence ovarian aging may provide strategies to delay or alleviate physiological alterations that take place in postmenopausal women. The germ cell-deficient Wv mice recapitulate follicle loss, prolong postreproductive lifespan, and model many physiological changes that take place in postmenopausal women. Here, using genetic and pharmacological approaches, we found that inhibition of cyclooxygenase-1 but not cyclooxygenase-2 in Wv mice delays germ cell depletion and preserves ovarian follicles. Cyclooxygenase-1 inhibition slows down follicle maturation at the conversion of primary to secondary follicles and prolongs postnatal ovarian follicle lifespan. The current study suggests that inhibition of cyclooxygenase-1 may be able to delay ovarian aging and modulate menopausal timing.

Original languageEnglish
Article numberArticle 103
JournalBiology of Reproduction
Volume89
Issue number4
DOIs
StatePublished - Jan 1 2013

Fingerprint

Cyclooxygenase 1
Ovarian Follicle
Menopause
Germ Cells
Menstruation
Cyclooxygenase 2
Pharmacology
Health

Keywords

  • Cyclooxygenase
  • Follicular development
  • Menopause
  • Ovarian follicles

ASJC Scopus subject areas

  • Cell Biology

Cite this

Cyclooxygenase-1 inhibition prolongs postnatal ovarian follicle lifespan in mice. / Smith, Elizabeth R.; Yang, Wan Lin; Yeasky, Toni; Smedberg, Jennifer; Cai, Kathy Q.; Xu, Xiangxi.

In: Biology of Reproduction, Vol. 89, No. 4, Article 103, 01.01.2013.

Research output: Contribution to journalArticle

Smith, Elizabeth R. ; Yang, Wan Lin ; Yeasky, Toni ; Smedberg, Jennifer ; Cai, Kathy Q. ; Xu, Xiangxi. / Cyclooxygenase-1 inhibition prolongs postnatal ovarian follicle lifespan in mice. In: Biology of Reproduction. 2013 ; Vol. 89, No. 4.
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