Cyclodextrin mediated solvent-free enantioselective photocyclization of N-alkyl pyridones

J. Shailaja, S. Karthikeyan, V. Ramamurthy

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Irradiation of N-methyl pyridone and N-ethyl pyridone included in β-cyclodextrin yields the photocylized product, chiral 2-azabicyclo[2.2.0]-hex-5-en-3-ones, in ∼60% enantiomeric excess. The inclusion complex is readily made by mechanically mixing the host β-cyclodextrin and the guest pyridone.

Original languageEnglish (US)
Pages (from-to)9335-9339
Number of pages5
JournalTetrahedron Letters
Volume43
Issue number51
DOIs
StatePublished - Dec 16 2002

Keywords

  • Chiral induction
  • Cyclodextrin
  • Inclusion complex
  • Pyridone

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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