Abstract
Irradiation of N-methyl pyridone and N-ethyl pyridone included in β-cyclodextrin yields the photocylized product, chiral 2-azabicyclo[2.2.0]-hex-5-en-3-ones, in ∼60% enantiomeric excess. The inclusion complex is readily made by mechanically mixing the host β-cyclodextrin and the guest pyridone.
Original language | English (US) |
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Pages (from-to) | 9335-9339 |
Number of pages | 5 |
Journal | Tetrahedron Letters |
Volume | 43 |
Issue number | 51 |
DOIs | |
State | Published - Dec 16 2002 |
Externally published | Yes |
Keywords
- Chiral induction
- Cyclodextrin
- Inclusion complex
- Pyridone
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery