Cyclin-dependent kinase 5 and insulin secretion

Christina Bark, Marjan Rupnik, Marko Jevsek, Slavena A. Mandic, Per Olof Berggren

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cyclin-dependent kinase 5 (Cdk5) is emerging as a multifunctional kinase involved in regulating numerous cellular processes. Lately, Cdk5 has also emerged as a key controller of regulated membrane fusion in secretory cells. The pancreatic β-cell is highly specialized to secrete insulin in response to elevated glucose concentrations in the blood. The final biochemical events leading to insulin release from the β-cell are governed by a secretion apparatus that is similar to the presynaptic machinery mediating synaptic transmission in neuronal networks. We now summarize recent developments in the field of Cdk5 and regulated exocytosis and also present some novel findings regarding Cdk5's effect on insulin secretion.

Original languageEnglish
Title of host publicationCyclin Dependent Kinase 5 (Cdk5)
PublisherSpringer US
Pages145-158
Number of pages14
ISBN (Print)9780387788876, 9780387788869
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

Fingerprint

Cyclin-Dependent Kinase 5
Insulin
Membrane Fusion
Exocytosis
Synaptic Transmission
Phosphotransferases
Glucose

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Bark, C., Rupnik, M., Jevsek, M., Mandic, S. A., & Berggren, P. O. (2008). Cyclin-dependent kinase 5 and insulin secretion. In Cyclin Dependent Kinase 5 (Cdk5) (pp. 145-158). Springer US. https://doi.org/10.1007/978-0-387-78887-6_11

Cyclin-dependent kinase 5 and insulin secretion. / Bark, Christina; Rupnik, Marjan; Jevsek, Marko; Mandic, Slavena A.; Berggren, Per Olof.

Cyclin Dependent Kinase 5 (Cdk5). Springer US, 2008. p. 145-158.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bark, C, Rupnik, M, Jevsek, M, Mandic, SA & Berggren, PO 2008, Cyclin-dependent kinase 5 and insulin secretion. in Cyclin Dependent Kinase 5 (Cdk5). Springer US, pp. 145-158. https://doi.org/10.1007/978-0-387-78887-6_11
Bark C, Rupnik M, Jevsek M, Mandic SA, Berggren PO. Cyclin-dependent kinase 5 and insulin secretion. In Cyclin Dependent Kinase 5 (Cdk5). Springer US. 2008. p. 145-158 https://doi.org/10.1007/978-0-387-78887-6_11
Bark, Christina ; Rupnik, Marjan ; Jevsek, Marko ; Mandic, Slavena A. ; Berggren, Per Olof. / Cyclin-dependent kinase 5 and insulin secretion. Cyclin Dependent Kinase 5 (Cdk5). Springer US, 2008. pp. 145-158
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