Abstract
Self-assembled monolayers of alkanethiols on gold have been reported to be highly stable for voltammetry experiments in aqueous electrolyte. In this work a gold electrode has been modified by first depositing one layer of an alkylthiol (S-C18) and then coating by phospholipid multilayers. Voltammetric oxidation of the antipsychotic chlorpromazine at this two-step modified electrode was followed by means of cyclic voltammetry measurements. The results give important information concerning the behaviour of the pharmacological agent at the lipid-water interface. Measurements made using the pre-concentration method allow good sensitivity improvement after 5 min accumulation time. The ability of chlorpromazine to penetrate inside the phospholipid multilayers has also been investigated under different conditions such as the nature of the phospholipid and the pH of the medium. The accumulation process seems to be closely related to the charge carried by the phospholipid and by the molecule, while the incorporation process seems to be independent of the charge carried by the phospholipid and dependent of the degree of fluidity of their hydrocarbon chains. We found through this work that the acid-base equilibrium of chlorpromazine together with its amphiphilic properties (as compared with the results of similar studies on phenothiazine) could be responsible for governing the principal aspects of the drug's behaviour toward biological membranes.
| Original language | English |
|---|---|
| Pages (from-to) | 143-147 |
| Number of pages | 5 |
| Journal | Journal of Solid State Electrochemistry |
| Volume | 1 |
| Issue number | 2 |
| State | Published - Dec 1 1997 |
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Keywords
- Chlorpromazine
- Cyclic voltammetry
- Modified gold electrode
- Penetration
- Phospholipid
ASJC Scopus subject areas
- Electrochemistry
Cite this
Cyclic voltammetric studies of the antipsychotic chlorpromazine using an alkylthiol/phospholipid-modified gold electrode. / Temsamani, Khalid R.; Fahmi, Taoufik; Bouchta, Dounia; Kaifer, Angel.
In: Journal of Solid State Electrochemistry, Vol. 1, No. 2, 01.12.1997, p. 143-147.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cyclic voltammetric studies of the antipsychotic chlorpromazine using an alkylthiol/phospholipid-modified gold electrode
AU - Temsamani, Khalid R.
AU - Fahmi, Taoufik
AU - Bouchta, Dounia
AU - Kaifer, Angel
PY - 1997/12/1
Y1 - 1997/12/1
N2 - Self-assembled monolayers of alkanethiols on gold have been reported to be highly stable for voltammetry experiments in aqueous electrolyte. In this work a gold electrode has been modified by first depositing one layer of an alkylthiol (S-C18) and then coating by phospholipid multilayers. Voltammetric oxidation of the antipsychotic chlorpromazine at this two-step modified electrode was followed by means of cyclic voltammetry measurements. The results give important information concerning the behaviour of the pharmacological agent at the lipid-water interface. Measurements made using the pre-concentration method allow good sensitivity improvement after 5 min accumulation time. The ability of chlorpromazine to penetrate inside the phospholipid multilayers has also been investigated under different conditions such as the nature of the phospholipid and the pH of the medium. The accumulation process seems to be closely related to the charge carried by the phospholipid and by the molecule, while the incorporation process seems to be independent of the charge carried by the phospholipid and dependent of the degree of fluidity of their hydrocarbon chains. We found through this work that the acid-base equilibrium of chlorpromazine together with its amphiphilic properties (as compared with the results of similar studies on phenothiazine) could be responsible for governing the principal aspects of the drug's behaviour toward biological membranes.
AB - Self-assembled monolayers of alkanethiols on gold have been reported to be highly stable for voltammetry experiments in aqueous electrolyte. In this work a gold electrode has been modified by first depositing one layer of an alkylthiol (S-C18) and then coating by phospholipid multilayers. Voltammetric oxidation of the antipsychotic chlorpromazine at this two-step modified electrode was followed by means of cyclic voltammetry measurements. The results give important information concerning the behaviour of the pharmacological agent at the lipid-water interface. Measurements made using the pre-concentration method allow good sensitivity improvement after 5 min accumulation time. The ability of chlorpromazine to penetrate inside the phospholipid multilayers has also been investigated under different conditions such as the nature of the phospholipid and the pH of the medium. The accumulation process seems to be closely related to the charge carried by the phospholipid and by the molecule, while the incorporation process seems to be independent of the charge carried by the phospholipid and dependent of the degree of fluidity of their hydrocarbon chains. We found through this work that the acid-base equilibrium of chlorpromazine together with its amphiphilic properties (as compared with the results of similar studies on phenothiazine) could be responsible for governing the principal aspects of the drug's behaviour toward biological membranes.
KW - Chlorpromazine
KW - Cyclic voltammetry
KW - Modified gold electrode
KW - Penetration
KW - Phospholipid
UR - http://www.scopus.com/inward/record.url?scp=0344288080&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0344288080&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0344288080
VL - 1
SP - 143
EP - 147
JO - Journal of Solid State Electrochemistry
JF - Journal of Solid State Electrochemistry
SN - 1432-8488
IS - 2
ER -