Cyclic voltammetric studies of the antipsychotic chlorpromazine using an alkylthiol/phospholipid-modified gold electrode

Khalid R. Temsamani, Taoufik Fahmi, Dounia Bouchta, Angel E. Kaifer

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Self-assembled monolayers of alkanethiols on gold have been reported to be highly stable for voltammetry experiments in aqueous electrolyte. In this work a gold electrode has been modified by first depositing one layer of an alkylthiol (S-C18) and then coating by phospholipid multilayers. Voltammetric oxidation of the antipsychotic chlorpromazine at this two-step modified electrode was followed by means of cyclic voltammetry measurements. The results give important information concerning the behaviour of the pharmacological agent at the lipid-water interface. Measurements made using the pre-concentration method allow good sensitivity improvement after 5 min accumulation time. The ability of chlorpromazine to penetrate inside the phospholipid multilayers has also been investigated under different conditions such as the nature of the phospholipid and the pH of the medium. The accumulation process seems to be closely related to the charge carried by the phospholipid and by the molecule, while the incorporation process seems to be independent of the charge carried by the phospholipid and dependent of the degree of fluidity of their hydrocarbon chains. We found through this work that the acid-base equilibrium of chlorpromazine together with its amphiphilic properties (as compared with the results of similar studies on phenothiazine) could be responsible for governing the principal aspects of the drug's behaviour toward biological membranes.

Original languageEnglish (US)
Pages (from-to)143-147
Number of pages5
JournalJournal of Solid State Electrochemistry
Volume1
Issue number2
DOIs
StatePublished - Jan 1 1997

Keywords

  • Chlorpromazine
  • Cyclic voltammetry
  • Modified gold electrode
  • Penetration
  • Phospholipid

ASJC Scopus subject areas

  • Electrochemistry

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