Cyanobacterial toxins in neurodegeneration

Deborah C. Mash

doi:10.1212/01.CON.0000337997.85667.1f

Cyanobacterial toxins in neurodegeneration

Deborah C. Mash

Neurology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Cyanobacteria can generate molecules that are toxic to human health, including the production of neurotoxic substances. This chapter focuses on β-N-methylamino-Lalanine (BMAA) as an example of a high-exposure cyanobacterial neurotoxin that has been linked to occurrence of ALS-parkinsonism-dementia complex of Guam. The historical account of the BMAA hypothesis is presented, together with a discussion of possible mechanisms underlying the neurotoxic effects of this nonprotein amino acid. This chapter also alludes to the globalimportance of marine cyanobacterial blooms and the fate of BMAA in marine and freshwater ecosystems, which may contribute to sporadic neurodegenerative diseases occurring outsideof Guam.

Original language	English (US)
Pages (from-to)	138-149
Number of pages	12
Journal	CONTINUUM Lifelong Learning in Neurology
Volume	14
Issue number	5
DOIs	https://doi.org/10.1212/01.CON.0000337997.85667.1f
State	Published - Oct 1 2008

ASJC Scopus subject areas

Clinical Neurology
Genetics(clinical)

UN SDGs

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AB - Cyanobacteria can generate molecules that are toxic to human health, including the production of neurotoxic substances. This chapter focuses on β-N-methylamino-Lalanine (BMAA) as an example of a high-exposure cyanobacterial neurotoxin that has been linked to occurrence of ALS-parkinsonism-dementia complex of Guam. The historical account of the BMAA hypothesis is presented, together with a discussion of possible mechanisms underlying the neurotoxic effects of this nonprotein amino acid. This chapter also alludes to the globalimportance of marine cyanobacterial blooms and the fate of BMAA in marine and freshwater ecosystems, which may contribute to sporadic neurodegenerative diseases occurring outsideof Guam.

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Cyanobacterial toxins in neurodegeneration

Abstract

ASJC Scopus subject areas

UN SDGs

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