Cutting edge: The Th1 response inhibits the generation of peripheral regulatory T cells

David Caretto, Shoshana D. Katzman, Alejandro V. Villarino, Eugenio Gallo, Abul K. Abbas

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

The possibility that effector T cells can be converted into forkhead box P3+ regulatory T cells (Tregs) has potential therapeutic implications. To analyze the relationship between Th1 effectors and Tregs, we have used a model of systemic autoimmunity in which both effector and Tregs arise from a single population specific for a transgene-encoded systemic protein. In vitro, the presence of IFN-γ inhibits Treg generation during activation. Using IFN-γ reporter mice, we demonstrate that IFN-γ-producing cells tend not to develop into Tregs, and Th1 priming of T cells prior to cell transfer limits the number of fork-head box P3+ T cells generated in vivo. Moreover, transfer of IFN-γ-/- or STAT1-/- T cells resulted in an increase in the number of Tregs.These data support a role for Th1 effector molecules and transcription factors in the control of peripheral Treg generation and demonstrates the limited plasticity of Th1 populations.

Original languageEnglish (US)
Pages (from-to)30-34
Number of pages5
JournalJournal of Immunology
Volume184
Issue number1
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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