Cutting Edge: Early IL-4 Production Governs the Requirement for IL-27-WSX-1 Signaling in the Development of Protective Th1 Cytokine Responses following Leishmania major Infection

David Artis, Leanne M. Johnson, Karen Joyce, Christiaan Saris, Alejandro Villarino, Christopher A. Hunter, Phillip Scott

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

There are conflicting reports on the requirements for the IL-27-WSX-1 pathway in the development of Th type 1 responses and resistance to intracellular pathogens; although early IFN-γ production and resistance to Leishmania major are impaired in the absence of WSX-1 signaling, WSX-1 -/- mice generate robust IFN-γ responses and control infection with other intracellular protozoan pathogens. In this report, we resolve these conflicting observations and demonstrate that, in the absence of IL-4, WSX-1 is not required for early IFN-γ production and control of L. major. Thus, the requirement for WSX-1 signaling in Th type 1 cell differentiation is restricted to conditions in which IL-4 is produced.

Original languageEnglish (US)
Pages (from-to)4672-4675
Number of pages4
JournalJournal of Immunology
Volume172
Issue number8
DOIs
StatePublished - Apr 15 2004
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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