Abstract
Patients undergoing cancer chemotherapy are often challenging to physicians from a management standpoint due to an unfortunate combination of general poor health, immunosuppression, and multi-drug regimens. Several chemotherapeutic agents are associated with well-described mucocutaneous toxicities. This chapter will address the commonly encountered adverse events associated with traditional chemotherapy medications such as chemotherapy- induced alopecia, mucositis, extravasation reactions, dyschromia, and acral erythema, among others. This will be followed by a discussion of the cutaneous toxicities associated with newer agents, namely, targeted therapies such as monoclonal antibodies and tyrosine kinase inhibitors. Finally, a brief discussion of radiation recall and enhancement is also included. By addressing important considerations in the recognition, diagnosis, and management of the cutaneous effects of cancer treatment, additional morbidity and potential mortality can be avoided in this already at-risk patient population.
| Original language | English (US) |
|---|---|
| Title of host publication | Skin Diseases in the Immunocompromised |
| Publisher | Springer-Verlag London Ltd |
| Pages | 87-98 |
| Number of pages | 12 |
| Volume | 9781447164791 |
| ISBN (Print) | 9781447164791, 1447164784, 9781447164784 |
| DOIs | |
| State | Published - May 1 2014 |
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Keywords
- Alopecia
- Blocking antibodies
- Cancer
- Chemotherapy
- Immunosuppression
- Kinase inhibitors
- Mucocutaneous
- Mucositis
ASJC Scopus subject areas
- Medicine(all)
Cite this
Cutaneous reactions to chemotherapy. / Savas, Jessica A.; Mahtani, Reshma.
Skin Diseases in the Immunocompromised. Vol. 9781447164791 Springer-Verlag London Ltd, 2014. p. 87-98.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Cutaneous reactions to chemotherapy
AU - Savas, Jessica A.
AU - Mahtani, Reshma
PY - 2014/5/1
Y1 - 2014/5/1
N2 - Patients undergoing cancer chemotherapy are often challenging to physicians from a management standpoint due to an unfortunate combination of general poor health, immunosuppression, and multi-drug regimens. Several chemotherapeutic agents are associated with well-described mucocutaneous toxicities. This chapter will address the commonly encountered adverse events associated with traditional chemotherapy medications such as chemotherapy- induced alopecia, mucositis, extravasation reactions, dyschromia, and acral erythema, among others. This will be followed by a discussion of the cutaneous toxicities associated with newer agents, namely, targeted therapies such as monoclonal antibodies and tyrosine kinase inhibitors. Finally, a brief discussion of radiation recall and enhancement is also included. By addressing important considerations in the recognition, diagnosis, and management of the cutaneous effects of cancer treatment, additional morbidity and potential mortality can be avoided in this already at-risk patient population.
AB - Patients undergoing cancer chemotherapy are often challenging to physicians from a management standpoint due to an unfortunate combination of general poor health, immunosuppression, and multi-drug regimens. Several chemotherapeutic agents are associated with well-described mucocutaneous toxicities. This chapter will address the commonly encountered adverse events associated with traditional chemotherapy medications such as chemotherapy- induced alopecia, mucositis, extravasation reactions, dyschromia, and acral erythema, among others. This will be followed by a discussion of the cutaneous toxicities associated with newer agents, namely, targeted therapies such as monoclonal antibodies and tyrosine kinase inhibitors. Finally, a brief discussion of radiation recall and enhancement is also included. By addressing important considerations in the recognition, diagnosis, and management of the cutaneous effects of cancer treatment, additional morbidity and potential mortality can be avoided in this already at-risk patient population.
KW - Alopecia
KW - Blocking antibodies
KW - Cancer
KW - Chemotherapy
KW - Immunosuppression
KW - Kinase inhibitors
KW - Mucocutaneous
KW - Mucositis
UR - http://www.scopus.com/inward/record.url?scp=84930155720&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930155720&partnerID=8YFLogxK
U2 - 10.1007/978-1-4471-6479-1_8
DO - 10.1007/978-1-4471-6479-1_8
M3 - Chapter
SN - 9781447164791
SN - 1447164784
SN - 9781447164784
VL - 9781447164791
SP - 87
EP - 98
BT - Skin Diseases in the Immunocompromised
PB - Springer-Verlag London Ltd
ER -