Cutaneous reactions to alimentary tract medications: Results of a seven-year surveillance program and review of the literature

L. Naldi, C. Ferri, S. De Sanctis, T. Cainelli, A. Rebora, G. Tognoni, A. Peserico, F. Grimaldi-Filioli, P. A. Villano, C. Moscariello, V. Guerrera, M. Florio, M. Pisani, F. Locati, G. Falgheri, A. Di Landro, A. Barcella, A. Reseghetti, G. Imberti, A. De BitontoA. Mariani, B. Pansera, P. Puiatti, M. Fassino, M. Tomidei, G. Doveil, M. Annunziata, A. M. Zina, M. Forte, R. Filotico, C. Foti, G. Angelini, G. A. Vena, F. Arcangeli, L. Brighi, S. Feletti, M. Leardini, M. Polverelli, G. Landi, Antonella Tosti, C. Misciali, A. D'Antuono, V. Zucchelli, C. Varotti, N. Balato, S. De Rosa, F. Bordone, C. Patruno, P. Santoianni, A. R. Virgili, R. Strumia, V. Colombo, A. Negrini, A. Califano, P. Marinaro, M. I. Riva, E. Gennari, G. Galbiati, G. Pasolini, A. Manganoni, C. Leali, A. Carlino, D. Schena, A. Barba, S. Veraldi, G. Rizzitelli, R. Caputo, C. Veller-Fornasa, S. Poletto, A. Peserico, F. Cusano, A. G. Galluccio, M. Capozzi, A. Burroni, A. Nigro, A. Farris, A. Fanti, P. E. Lombardi, S. Di Iorio, R. Becchilega, P. Perno, P. Lisi, A. Pestarino, A. Annonide, L. Massone, M. Iannantuono, M. Lomuto, E. Robert, F. Rongioletti, R. Betti, C. Crosti, T. Di Prima, A. Sapuppo, A. Locatelli, F. Saggiorato, G. Fenizi, L. Altobella, S. Moretti, L. Barcella

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: No systematic review of skin reactions to alimentary tract medications is available in the literature. Objective: We reviewed the reactions to alimentary tract medications reported to the surveillance system of the Italian Group for Epidemiologic Research in Dermatology (GISED). Methods: Between January 1988 and December 1994, 202 dermatologists in Italy reported to the coordinating center of GISED all the adverse reactions they observed during prespecified 2-month monitoring periods. Reactions classified under ATC codes A02-A04, A06, A07 and A09 were used for this analysis. Results: Of 2,789 reactions, 48 were attributed to alimentary tract medications. Urticaria/angioedema and exanthemas accounted for about 70% of these reactions. Fixed eruptions and lichenoid dermatitis accounted for a large part of the remaining reactions. Antiulcers and antiemetics appeared remarkably safe. Conclusion: Our data are reassuring with regard to the cutaneous reaction profile of several drugs taken for diseases of the alimentary tract.

Original languageEnglish
Pages (from-to)11-16
Number of pages6
JournalDermatology
Volume193
Issue number1
StatePublished - Aug 17 1996
Externally publishedYes

Fingerprint

Lichenoid Eruptions
Angioedema
Skin
Antiemetics
Urticaria
Dermatitis
Dermatology
Exanthema
varespladib methyl
Italy
Research
Pharmaceutical Preparations
Dermatologists

Keywords

  • Adverse drug reactions
  • Alimentary tract medications
  • Post-marketing surveillance
  • Skin

ASJC Scopus subject areas

  • Dermatology

Cite this

Naldi, L., Ferri, C., De Sanctis, S., Cainelli, T., Rebora, A., Tognoni, G., ... Barcella, L. (1996). Cutaneous reactions to alimentary tract medications: Results of a seven-year surveillance program and review of the literature. Dermatology, 193(1), 11-16.

Cutaneous reactions to alimentary tract medications : Results of a seven-year surveillance program and review of the literature. / Naldi, L.; Ferri, C.; De Sanctis, S.; Cainelli, T.; Rebora, A.; Tognoni, G.; Peserico, A.; Grimaldi-Filioli, F.; Villano, P. A.; Moscariello, C.; Guerrera, V.; Florio, M.; Pisani, M.; Locati, F.; Falgheri, G.; Di Landro, A.; Barcella, A.; Reseghetti, A.; Imberti, G.; De Bitonto, A.; Mariani, A.; Pansera, B.; Puiatti, P.; Fassino, M.; Tomidei, M.; Doveil, G.; Annunziata, M.; Zina, A. M.; Forte, M.; Filotico, R.; Foti, C.; Angelini, G.; Vena, G. A.; Arcangeli, F.; Brighi, L.; Feletti, S.; Leardini, M.; Polverelli, M.; Landi, G.; Tosti, Antonella; Misciali, C.; D'Antuono, A.; Zucchelli, V.; Varotti, C.; Balato, N.; De Rosa, S.; Bordone, F.; Patruno, C.; Santoianni, P.; Virgili, A. R.; Strumia, R.; Colombo, V.; Negrini, A.; Califano, A.; Marinaro, P.; Riva, M. I.; Gennari, E.; Galbiati, G.; Pasolini, G.; Manganoni, A.; Leali, C.; Carlino, A.; Schena, D.; Barba, A.; Veraldi, S.; Rizzitelli, G.; Caputo, R.; Veller-Fornasa, C.; Poletto, S.; Peserico, A.; Cusano, F.; Galluccio, A. G.; Capozzi, M.; Burroni, A.; Nigro, A.; Farris, A.; Fanti, A.; Lombardi, P. E.; Di Iorio, S.; Becchilega, R.; Perno, P.; Lisi, P.; Pestarino, A.; Annonide, A.; Massone, L.; Iannantuono, M.; Lomuto, M.; Robert, E.; Rongioletti, F.; Betti, R.; Crosti, C.; Di Prima, T.; Sapuppo, A.; Locatelli, A.; Saggiorato, F.; Fenizi, G.; Altobella, L.; Moretti, S.; Barcella, L.

In: Dermatology, Vol. 193, No. 1, 17.08.1996, p. 11-16.

Research output: Contribution to journalArticle

Naldi, L, Ferri, C, De Sanctis, S, Cainelli, T, Rebora, A, Tognoni, G, Peserico, A, Grimaldi-Filioli, F, Villano, PA, Moscariello, C, Guerrera, V, Florio, M, Pisani, M, Locati, F, Falgheri, G, Di Landro, A, Barcella, A, Reseghetti, A, Imberti, G, De Bitonto, A, Mariani, A, Pansera, B, Puiatti, P, Fassino, M, Tomidei, M, Doveil, G, Annunziata, M, Zina, AM, Forte, M, Filotico, R, Foti, C, Angelini, G, Vena, GA, Arcangeli, F, Brighi, L, Feletti, S, Leardini, M, Polverelli, M, Landi, G, Tosti, A, Misciali, C, D'Antuono, A, Zucchelli, V, Varotti, C, Balato, N, De Rosa, S, Bordone, F, Patruno, C, Santoianni, P, Virgili, AR, Strumia, R, Colombo, V, Negrini, A, Califano, A, Marinaro, P, Riva, MI, Gennari, E, Galbiati, G, Pasolini, G, Manganoni, A, Leali, C, Carlino, A, Schena, D, Barba, A, Veraldi, S, Rizzitelli, G, Caputo, R, Veller-Fornasa, C, Poletto, S, Peserico, A, Cusano, F, Galluccio, AG, Capozzi, M, Burroni, A, Nigro, A, Farris, A, Fanti, A, Lombardi, PE, Di Iorio, S, Becchilega, R, Perno, P, Lisi, P, Pestarino, A, Annonide, A, Massone, L, Iannantuono, M, Lomuto, M, Robert, E, Rongioletti, F, Betti, R, Crosti, C, Di Prima, T, Sapuppo, A, Locatelli, A, Saggiorato, F, Fenizi, G, Altobella, L, Moretti, S & Barcella, L 1996, 'Cutaneous reactions to alimentary tract medications: Results of a seven-year surveillance program and review of the literature', Dermatology, vol. 193, no. 1, pp. 11-16.
Naldi L, Ferri C, De Sanctis S, Cainelli T, Rebora A, Tognoni G et al. Cutaneous reactions to alimentary tract medications: Results of a seven-year surveillance program and review of the literature. Dermatology. 1996 Aug 17;193(1):11-16.
Naldi, L. ; Ferri, C. ; De Sanctis, S. ; Cainelli, T. ; Rebora, A. ; Tognoni, G. ; Peserico, A. ; Grimaldi-Filioli, F. ; Villano, P. A. ; Moscariello, C. ; Guerrera, V. ; Florio, M. ; Pisani, M. ; Locati, F. ; Falgheri, G. ; Di Landro, A. ; Barcella, A. ; Reseghetti, A. ; Imberti, G. ; De Bitonto, A. ; Mariani, A. ; Pansera, B. ; Puiatti, P. ; Fassino, M. ; Tomidei, M. ; Doveil, G. ; Annunziata, M. ; Zina, A. M. ; Forte, M. ; Filotico, R. ; Foti, C. ; Angelini, G. ; Vena, G. A. ; Arcangeli, F. ; Brighi, L. ; Feletti, S. ; Leardini, M. ; Polverelli, M. ; Landi, G. ; Tosti, Antonella ; Misciali, C. ; D'Antuono, A. ; Zucchelli, V. ; Varotti, C. ; Balato, N. ; De Rosa, S. ; Bordone, F. ; Patruno, C. ; Santoianni, P. ; Virgili, A. R. ; Strumia, R. ; Colombo, V. ; Negrini, A. ; Califano, A. ; Marinaro, P. ; Riva, M. I. ; Gennari, E. ; Galbiati, G. ; Pasolini, G. ; Manganoni, A. ; Leali, C. ; Carlino, A. ; Schena, D. ; Barba, A. ; Veraldi, S. ; Rizzitelli, G. ; Caputo, R. ; Veller-Fornasa, C. ; Poletto, S. ; Peserico, A. ; Cusano, F. ; Galluccio, A. G. ; Capozzi, M. ; Burroni, A. ; Nigro, A. ; Farris, A. ; Fanti, A. ; Lombardi, P. E. ; Di Iorio, S. ; Becchilega, R. ; Perno, P. ; Lisi, P. ; Pestarino, A. ; Annonide, A. ; Massone, L. ; Iannantuono, M. ; Lomuto, M. ; Robert, E. ; Rongioletti, F. ; Betti, R. ; Crosti, C. ; Di Prima, T. ; Sapuppo, A. ; Locatelli, A. ; Saggiorato, F. ; Fenizi, G. ; Altobella, L. ; Moretti, S. ; Barcella, L. / Cutaneous reactions to alimentary tract medications : Results of a seven-year surveillance program and review of the literature. In: Dermatology. 1996 ; Vol. 193, No. 1. pp. 11-16.
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title = "Cutaneous reactions to alimentary tract medications: Results of a seven-year surveillance program and review of the literature",
abstract = "Background: No systematic review of skin reactions to alimentary tract medications is available in the literature. Objective: We reviewed the reactions to alimentary tract medications reported to the surveillance system of the Italian Group for Epidemiologic Research in Dermatology (GISED). Methods: Between January 1988 and December 1994, 202 dermatologists in Italy reported to the coordinating center of GISED all the adverse reactions they observed during prespecified 2-month monitoring periods. Reactions classified under ATC codes A02-A04, A06, A07 and A09 were used for this analysis. Results: Of 2,789 reactions, 48 were attributed to alimentary tract medications. Urticaria/angioedema and exanthemas accounted for about 70{\%} of these reactions. Fixed eruptions and lichenoid dermatitis accounted for a large part of the remaining reactions. Antiulcers and antiemetics appeared remarkably safe. Conclusion: Our data are reassuring with regard to the cutaneous reaction profile of several drugs taken for diseases of the alimentary tract.",
keywords = "Adverse drug reactions, Alimentary tract medications, Post-marketing surveillance, Skin",
author = "L. Naldi and C. Ferri and {De Sanctis}, S. and T. Cainelli and A. Rebora and G. Tognoni and A. Peserico and F. Grimaldi-Filioli and Villano, {P. A.} and C. Moscariello and V. Guerrera and M. Florio and M. Pisani and F. Locati and G. Falgheri and {Di Landro}, A. and A. Barcella and A. Reseghetti and G. Imberti and {De Bitonto}, A. and A. Mariani and B. Pansera and P. Puiatti and M. Fassino and M. Tomidei and G. Doveil and M. Annunziata and Zina, {A. M.} and M. Forte and R. Filotico and C. Foti and G. Angelini and Vena, {G. A.} and F. Arcangeli and L. Brighi and S. Feletti and M. Leardini and M. Polverelli and G. Landi and Antonella Tosti and C. Misciali and A. D'Antuono and V. Zucchelli and C. Varotti and N. Balato and {De Rosa}, S. and F. Bordone and C. Patruno and P. Santoianni and Virgili, {A. R.} and R. Strumia and V. Colombo and A. Negrini and A. Califano and P. Marinaro and Riva, {M. I.} and E. Gennari and G. Galbiati and G. Pasolini and A. Manganoni and C. Leali and A. Carlino and D. Schena and A. Barba and S. Veraldi and G. Rizzitelli and R. Caputo and C. Veller-Fornasa and S. Poletto and A. Peserico and F. Cusano and Galluccio, {A. G.} and M. Capozzi and A. Burroni and A. Nigro and A. Farris and A. Fanti and Lombardi, {P. E.} and {Di Iorio}, S. and R. Becchilega and P. Perno and P. Lisi and A. Pestarino and A. Annonide and L. Massone and M. Iannantuono and M. Lomuto and E. Robert and F. Rongioletti and R. Betti and C. Crosti and {Di Prima}, T. and A. Sapuppo and A. Locatelli and F. Saggiorato and G. Fenizi and L. Altobella and S. Moretti and L. Barcella",
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month = "8",
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journal = "Dermatology",
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TY - JOUR

T1 - Cutaneous reactions to alimentary tract medications

T2 - Results of a seven-year surveillance program and review of the literature

AU - Naldi, L.

AU - Ferri, C.

AU - De Sanctis, S.

AU - Cainelli, T.

AU - Rebora, A.

AU - Tognoni, G.

AU - Peserico, A.

AU - Grimaldi-Filioli, F.

AU - Villano, P. A.

AU - Moscariello, C.

AU - Guerrera, V.

AU - Florio, M.

AU - Pisani, M.

AU - Locati, F.

AU - Falgheri, G.

AU - Di Landro, A.

AU - Barcella, A.

AU - Reseghetti, A.

AU - Imberti, G.

AU - De Bitonto, A.

AU - Mariani, A.

AU - Pansera, B.

AU - Puiatti, P.

AU - Fassino, M.

AU - Tomidei, M.

AU - Doveil, G.

AU - Annunziata, M.

AU - Zina, A. M.

AU - Forte, M.

AU - Filotico, R.

AU - Foti, C.

AU - Angelini, G.

AU - Vena, G. A.

AU - Arcangeli, F.

AU - Brighi, L.

AU - Feletti, S.

AU - Leardini, M.

AU - Polverelli, M.

AU - Landi, G.

AU - Tosti, Antonella

AU - Misciali, C.

AU - D'Antuono, A.

AU - Zucchelli, V.

AU - Varotti, C.

AU - Balato, N.

AU - De Rosa, S.

AU - Bordone, F.

AU - Patruno, C.

AU - Santoianni, P.

AU - Virgili, A. R.

AU - Strumia, R.

AU - Colombo, V.

AU - Negrini, A.

AU - Califano, A.

AU - Marinaro, P.

AU - Riva, M. I.

AU - Gennari, E.

AU - Galbiati, G.

AU - Pasolini, G.

AU - Manganoni, A.

AU - Leali, C.

AU - Carlino, A.

AU - Schena, D.

AU - Barba, A.

AU - Veraldi, S.

AU - Rizzitelli, G.

AU - Caputo, R.

AU - Veller-Fornasa, C.

AU - Poletto, S.

AU - Peserico, A.

AU - Cusano, F.

AU - Galluccio, A. G.

AU - Capozzi, M.

AU - Burroni, A.

AU - Nigro, A.

AU - Farris, A.

AU - Fanti, A.

AU - Lombardi, P. E.

AU - Di Iorio, S.

AU - Becchilega, R.

AU - Perno, P.

AU - Lisi, P.

AU - Pestarino, A.

AU - Annonide, A.

AU - Massone, L.

AU - Iannantuono, M.

AU - Lomuto, M.

AU - Robert, E.

AU - Rongioletti, F.

AU - Betti, R.

AU - Crosti, C.

AU - Di Prima, T.

AU - Sapuppo, A.

AU - Locatelli, A.

AU - Saggiorato, F.

AU - Fenizi, G.

AU - Altobella, L.

AU - Moretti, S.

AU - Barcella, L.

PY - 1996/8/17

Y1 - 1996/8/17

N2 - Background: No systematic review of skin reactions to alimentary tract medications is available in the literature. Objective: We reviewed the reactions to alimentary tract medications reported to the surveillance system of the Italian Group for Epidemiologic Research in Dermatology (GISED). Methods: Between January 1988 and December 1994, 202 dermatologists in Italy reported to the coordinating center of GISED all the adverse reactions they observed during prespecified 2-month monitoring periods. Reactions classified under ATC codes A02-A04, A06, A07 and A09 were used for this analysis. Results: Of 2,789 reactions, 48 were attributed to alimentary tract medications. Urticaria/angioedema and exanthemas accounted for about 70% of these reactions. Fixed eruptions and lichenoid dermatitis accounted for a large part of the remaining reactions. Antiulcers and antiemetics appeared remarkably safe. Conclusion: Our data are reassuring with regard to the cutaneous reaction profile of several drugs taken for diseases of the alimentary tract.

AB - Background: No systematic review of skin reactions to alimentary tract medications is available in the literature. Objective: We reviewed the reactions to alimentary tract medications reported to the surveillance system of the Italian Group for Epidemiologic Research in Dermatology (GISED). Methods: Between January 1988 and December 1994, 202 dermatologists in Italy reported to the coordinating center of GISED all the adverse reactions they observed during prespecified 2-month monitoring periods. Reactions classified under ATC codes A02-A04, A06, A07 and A09 were used for this analysis. Results: Of 2,789 reactions, 48 were attributed to alimentary tract medications. Urticaria/angioedema and exanthemas accounted for about 70% of these reactions. Fixed eruptions and lichenoid dermatitis accounted for a large part of the remaining reactions. Antiulcers and antiemetics appeared remarkably safe. Conclusion: Our data are reassuring with regard to the cutaneous reaction profile of several drugs taken for diseases of the alimentary tract.

KW - Adverse drug reactions

KW - Alimentary tract medications

KW - Post-marketing surveillance

KW - Skin

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JO - Dermatology

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