Cutaneous Necrosis Associated With Intravenous Nafcillin Therapy

Samuel J. Tilden, J. Carl Craft, Roberto Cano, Robert S. Daum

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Four children had cutaneous necrosis associated with the administration of intravenous (IV) nafcillin sodium therapy. One patient required skin grafting. Hospitalization was prolonged with this patient and with one other in an effort to ensure healing. Adult rats, inoculated subcutaneously with nafcillin that was appropriately diluted according to manufacturer's recommendations, exhibited similar lesions. Oxacillin sodium, methicillin sodium, and cephalothin sodium, similarly diluted, did not necrose skin. Nafcillin should be added to the list of agents that produce similar toxic conditions. Frequent observation of the IV infusion site to detect extravasation may obviate this hazard. (Am J Dis Child 134:1046-1048, 1980.

Original languageEnglish (US)
Pages (from-to)1046-1048
Number of pages3
JournalAmerican Journal of Diseases of Children
Issue number11
StatePublished - Nov 1980

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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