Abstract
Background: Skin is our first line of defense against pathogenic microorganisms and the intimate contact between the epidermis and microbes has been well known. Purposes: Microbes that cause infection are associated with inflammatory dermatoses and exacerbate wound healing. It is therefore of vital importance to understand the intricacies of skin-microbiota interactions. However, until recently our knowledge and understanding was limited by being unable to deal with uncultivatable microorganisms, which constitute a large majority. Basic procedures: Recent advances in DNA sequencing methodologies, analysis tools and affordability led to major breakthroughs in defining the cutaneous microbiome. Main findings: We now know that four phyla, Actinobacteria, Firmicytes, Proteobacteria and Bacteroidetes, constitute preponderance of skin bacteria, while Malassezia dominates the fungal microbiome. We know that there are some 300 different bacteria inhabiting our skin. We also know that there is remarkable interpersonal variation, that the microbiota change over time, that different body sites harbor specific microbial arrays and that microbiota characteristically change in skin diseases. Principal conclusions: The recent advances led to appreciation that microbes are, for the most part, our allies, useful and protective, and that with increased understanding we will be able to harness our cutaneous friends to maintain and promote our health.
| Original language | English |
|---|---|
| Pages (from-to) | 82-87 |
| Number of pages | 6 |
| Journal | Journal of Dermatological Science |
| Volume | 75 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 2014 |
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Keywords
- 16S RNA
- Atopic dermatitis
- Bacteria
- Fungi
- Next generation sequencing
- Wound healing
ASJC Scopus subject areas
- Dermatology
- Biochemistry
- Molecular Biology
Cite this
Cutaneous microbiome studies in the times of affordable sequencing. / Tomic-Canic, Marjana; Perez-Perez, Guillermo I.; Blumenberg, Miroslav.
In: Journal of Dermatological Science, Vol. 75, No. 2, 01.01.2014, p. 82-87.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cutaneous microbiome studies in the times of affordable sequencing
AU - Tomic-Canic, Marjana
AU - Perez-Perez, Guillermo I.
AU - Blumenberg, Miroslav
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Background: Skin is our first line of defense against pathogenic microorganisms and the intimate contact between the epidermis and microbes has been well known. Purposes: Microbes that cause infection are associated with inflammatory dermatoses and exacerbate wound healing. It is therefore of vital importance to understand the intricacies of skin-microbiota interactions. However, until recently our knowledge and understanding was limited by being unable to deal with uncultivatable microorganisms, which constitute a large majority. Basic procedures: Recent advances in DNA sequencing methodologies, analysis tools and affordability led to major breakthroughs in defining the cutaneous microbiome. Main findings: We now know that four phyla, Actinobacteria, Firmicytes, Proteobacteria and Bacteroidetes, constitute preponderance of skin bacteria, while Malassezia dominates the fungal microbiome. We know that there are some 300 different bacteria inhabiting our skin. We also know that there is remarkable interpersonal variation, that the microbiota change over time, that different body sites harbor specific microbial arrays and that microbiota characteristically change in skin diseases. Principal conclusions: The recent advances led to appreciation that microbes are, for the most part, our allies, useful and protective, and that with increased understanding we will be able to harness our cutaneous friends to maintain and promote our health.
AB - Background: Skin is our first line of defense against pathogenic microorganisms and the intimate contact between the epidermis and microbes has been well known. Purposes: Microbes that cause infection are associated with inflammatory dermatoses and exacerbate wound healing. It is therefore of vital importance to understand the intricacies of skin-microbiota interactions. However, until recently our knowledge and understanding was limited by being unable to deal with uncultivatable microorganisms, which constitute a large majority. Basic procedures: Recent advances in DNA sequencing methodologies, analysis tools and affordability led to major breakthroughs in defining the cutaneous microbiome. Main findings: We now know that four phyla, Actinobacteria, Firmicytes, Proteobacteria and Bacteroidetes, constitute preponderance of skin bacteria, while Malassezia dominates the fungal microbiome. We know that there are some 300 different bacteria inhabiting our skin. We also know that there is remarkable interpersonal variation, that the microbiota change over time, that different body sites harbor specific microbial arrays and that microbiota characteristically change in skin diseases. Principal conclusions: The recent advances led to appreciation that microbes are, for the most part, our allies, useful and protective, and that with increased understanding we will be able to harness our cutaneous friends to maintain and promote our health.
KW - 16S RNA
KW - Atopic dermatitis
KW - Bacteria
KW - Fungi
KW - Next generation sequencing
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=84903649330&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84903649330&partnerID=8YFLogxK
U2 - 10.1016/j.jdermsci.2014.05.001
DO - 10.1016/j.jdermsci.2014.05.001
M3 - Article
C2 - 24933349
AN - SCOPUS:84903649330
VL - 75
SP - 82
EP - 87
JO - Journal of Dermatological Science
JF - Journal of Dermatological Science
SN - 0923-1811
IS - 2
ER -