Cutaneous innervation density in the allodynic form of postherpetic neuralgia

Michael C. Rowbotham, Gil Yosipovitch, M. Kari Connolly, Deborah Finlay, Grace Forde, Howard L. Fields

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

The relationship between deafferentation, sensory function, and pain was explored in 18 subjects with chronic postherpetic neuralgia (PHN). Subjective thresholds for warmth, cooling, and heat pain were measured quantitatively in painful skin areas and compared with normal contralateral skin. The severity of allodynia was graded in the affected area. Two 3-mm punch biopsies were taken from the most painful skin area and one from unaffected contralateral mirror-image skin. Immunofluorescence with the axonal marker PGP 9.5 revealed a reduction in density of innervation of the epidermis, the dermal-epidermal junction, and the eccrine sweat glands in PHN skin. In painful PHN skin, the reduction in innervation density was positively correlated with the magnitude of the thermal sensory deficits. However, loss of cutaneous innervation was inversely correlated with allodynia, indicating that surviving cutaneous primary afferent nociceptors that are spontaneously active and/or sensitized contribute to PHN pain and allodynia.

Original languageEnglish (US)
Pages (from-to)205-214
Number of pages10
JournalNeurobiology of Disease
Volume3
Issue number3
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

Fingerprint

Postherpetic Neuralgia
Skin
Hyperalgesia
Pain
Hot Temperature
Eccrine Glands
Sweat Glands
Nociceptors
Epidermis
Fluorescent Antibody Technique
Biopsy

ASJC Scopus subject areas

  • Neurology

Cite this

Cutaneous innervation density in the allodynic form of postherpetic neuralgia. / Rowbotham, Michael C.; Yosipovitch, Gil; Connolly, M. Kari; Finlay, Deborah; Forde, Grace; Fields, Howard L.

In: Neurobiology of Disease, Vol. 3, No. 3, 01.01.1996, p. 205-214.

Research output: Contribution to journalArticle

Rowbotham, Michael C. ; Yosipovitch, Gil ; Connolly, M. Kari ; Finlay, Deborah ; Forde, Grace ; Fields, Howard L. / Cutaneous innervation density in the allodynic form of postherpetic neuralgia. In: Neurobiology of Disease. 1996 ; Vol. 3, No. 3. pp. 205-214.
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