Punto de corte de espesor de tejido adiposo epicárdico para predecir síndrome metabólico en población venezolana

Translated title of the contribution: Cut-off point of epicardial adipose tissue thickness for predicting metabolic syndrome in Venezuelan population

Marcos M. Lima-Martínez, Mariela Paoli, José H. Donis, Rodolfo Odreman, Christopher Torres, Gianluca Iacobellis

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: To define an echocardiographically-assessed cut-off point for epicardial adipose tissue (EAT) thickness associated to metabolic syndrome (MS) components in Venezuelan subjects. Methods: Fifty-two subjects aged 20-65. years diagnosed with MS according to International Diabetes Federation criteria and 45. sex- and age-matched controls were selected. Blood glucose and plasma lipids were tested; EAT thickness and left ventricular mass were measured by echocardiography. Results: No significant age and sex differences were found between the two groups. Body weight, body mass index, waist circumference, and systolic and diastolic blood pressure were significantly higher (P = .0001) in the MS group. This group showed significantly higher levels of fasting blood glucose (P = .0001), total cholesterol (P = .002), LDL-C (P = .007), non-HDL-C (P = .0001), triglycerides (P = .0001), Tg-HDL-C ratio (P = .0001), and lower HDL-C levels (P = .0001) as compared to the control group. EAT thickness (P = .0001) and left ventricular mass (P = .017) were significantly higher in the MS group. The ROC curve showed an AUC of 0.852 (P = .0001) with a power of the test of 0.99. A 5-mm EAT thickness showed a sensitivity of 84.62% (95%. CI: 71.9-93.1) and a specificity of 71.11% (95%. CI: 55.7-83.6) for predicting MS. The odds ratio of this population for experiencing MS due to an EAT ≥ 5 mm was 8.25 (95%. CI: 3.15-21.56; P = .0001). Conclusion: An EAT value ≥ 5 mm has good sensitivity and specificity for predicting MS in the Venezuelan population.

Original languageSpanish
Pages (from-to)570-576
Number of pages7
JournalEndocrinologia y Nutricion
Volume60
Issue number10
DOIs
StatePublished - Dec 1 2013

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Adipose Tissue
Population
Blood Glucose
Blood Pressure
Waist Circumference
ROC Curve
Sex Characteristics
Area Under Curve
Echocardiography
Fasting
Triglycerides
Body Mass Index
Odds Ratio
Cholesterol
Body Weight
Lipids
Sensitivity and Specificity
Control Groups

Keywords

  • Epicardial adipose tissue
  • Epicardial fat
  • Hispanics
  • Metabolic syndrome

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Punto de corte de espesor de tejido adiposo epicárdico para predecir síndrome metabólico en población venezolana. / Lima-Martínez, Marcos M.; Paoli, Mariela; Donis, José H.; Odreman, Rodolfo; Torres, Christopher; Iacobellis, Gianluca.

In: Endocrinologia y Nutricion, Vol. 60, No. 10, 01.12.2013, p. 570-576.

Research output: Contribution to journalArticle

Lima-Martínez, Marcos M. ; Paoli, Mariela ; Donis, José H. ; Odreman, Rodolfo ; Torres, Christopher ; Iacobellis, Gianluca. / Punto de corte de espesor de tejido adiposo epicárdico para predecir síndrome metabólico en población venezolana. In: Endocrinologia y Nutricion. 2013 ; Vol. 60, No. 10. pp. 570-576.
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abstract = "Objective: To define an echocardiographically-assessed cut-off point for epicardial adipose tissue (EAT) thickness associated to metabolic syndrome (MS) components in Venezuelan subjects. Methods: Fifty-two subjects aged 20-65. years diagnosed with MS according to International Diabetes Federation criteria and 45. sex- and age-matched controls were selected. Blood glucose and plasma lipids were tested; EAT thickness and left ventricular mass were measured by echocardiography. Results: No significant age and sex differences were found between the two groups. Body weight, body mass index, waist circumference, and systolic and diastolic blood pressure were significantly higher (P = .0001) in the MS group. This group showed significantly higher levels of fasting blood glucose (P = .0001), total cholesterol (P = .002), LDL-C (P = .007), non-HDL-C (P = .0001), triglycerides (P = .0001), Tg-HDL-C ratio (P = .0001), and lower HDL-C levels (P = .0001) as compared to the control group. EAT thickness (P = .0001) and left ventricular mass (P = .017) were significantly higher in the MS group. The ROC curve showed an AUC of 0.852 (P = .0001) with a power of the test of 0.99. A 5-mm EAT thickness showed a sensitivity of 84.62{\%} (95{\%}. CI: 71.9-93.1) and a specificity of 71.11{\%} (95{\%}. CI: 55.7-83.6) for predicting MS. The odds ratio of this population for experiencing MS due to an EAT ≥ 5 mm was 8.25 (95{\%}. CI: 3.15-21.56; P = .0001). Conclusion: An EAT value ≥ 5 mm has good sensitivity and specificity for predicting MS in the Venezuelan population.",
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AU - Paoli, Mariela

AU - Donis, José H.

AU - Odreman, Rodolfo

AU - Torres, Christopher

AU - Iacobellis, Gianluca

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AB - Objective: To define an echocardiographically-assessed cut-off point for epicardial adipose tissue (EAT) thickness associated to metabolic syndrome (MS) components in Venezuelan subjects. Methods: Fifty-two subjects aged 20-65. years diagnosed with MS according to International Diabetes Federation criteria and 45. sex- and age-matched controls were selected. Blood glucose and plasma lipids were tested; EAT thickness and left ventricular mass were measured by echocardiography. Results: No significant age and sex differences were found between the two groups. Body weight, body mass index, waist circumference, and systolic and diastolic blood pressure were significantly higher (P = .0001) in the MS group. This group showed significantly higher levels of fasting blood glucose (P = .0001), total cholesterol (P = .002), LDL-C (P = .007), non-HDL-C (P = .0001), triglycerides (P = .0001), Tg-HDL-C ratio (P = .0001), and lower HDL-C levels (P = .0001) as compared to the control group. EAT thickness (P = .0001) and left ventricular mass (P = .017) were significantly higher in the MS group. The ROC curve showed an AUC of 0.852 (P = .0001) with a power of the test of 0.99. A 5-mm EAT thickness showed a sensitivity of 84.62% (95%. CI: 71.9-93.1) and a specificity of 71.11% (95%. CI: 55.7-83.6) for predicting MS. The odds ratio of this population for experiencing MS due to an EAT ≥ 5 mm was 8.25 (95%. CI: 3.15-21.56; P = .0001). Conclusion: An EAT value ≥ 5 mm has good sensitivity and specificity for predicting MS in the Venezuelan population.

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KW - Metabolic syndrome

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