Originally described by Harvey Cushing early in the last century,Cushing's syndrome is a multisystem disorder that results from sustained exposure to glucocorticoids, that when untreated results in a fivefold elevation in the relative cardiovascular mortality risk [12, 22]. The clinical spectrum of Cushing's syndrome is broad and although certain signs and symptoms suggest its presence, most clinical manifestations are nonspecific and are seldom pathognomonic. Furthermore, conditions of high prevalence such as hypertension, osteoporosis,depression and obesity may present with laboratory abnormalities of the hypothalamicpituitary-adrenal axis (i.e., increased cortisol urinary excretion rates and abnormal responses to dexamethasone suppression) that do not reflect sustained pathologic hypercortisolemia ("pseudo-Cushing's states").
|Original language||English (US)|
|Title of host publication||Adrenal Glands|
|Subtitle of host publication||Diagnostic Aspects and Surgical Therapy|
|Publisher||Springer Berlin Heidelberg|
|Number of pages||10|
|State||Published - Dec 1 2005|
ASJC Scopus subject areas