Cushing's syndrome

Alejandro Ayala, George Chrousos

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Originally described by Harvey Cushing early in the last century,Cushing's syndrome is a multisystem disorder that results from sustained exposure to glucocorticoids, that when untreated results in a fivefold elevation in the relative cardiovascular mortality risk [12, 22]. The clinical spectrum of Cushing's syndrome is broad and although certain signs and symptoms suggest its presence, most clinical manifestations are nonspecific and are seldom pathognomonic. Furthermore, conditions of high prevalence such as hypertension, osteoporosis,depression and obesity may present with laboratory abnormalities of the hypothalamicpituitary-adrenal axis (i.e., increased cortisol urinary excretion rates and abnormal responses to dexamethasone suppression) that do not reflect sustained pathologic hypercortisolemia ("pseudo-Cushing's states").

Original languageEnglish (US)
Title of host publicationAdrenal Glands
Subtitle of host publicationDiagnostic Aspects and Surgical Therapy
PublisherSpringer Berlin Heidelberg
Number of pages10
ISBN (Print)9783540410997
StatePublished - Dec 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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