Current views on collapsing glomerulopathy

Mamdouh Albaqumi, Laura Barisoni

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations

Abstract

Collapsing glomerulopathy is a proliferative disease defined by segmental or global wrinkling of the glomerular basement membranes associated with podocyte proliferation. These lesions are particularly poor responders to standard therapies. First described as an idiopathic disorder or following HIV infection, it is now associated with a broad group of diseases and different pathogenetic mechanisms, which participate in podocyte injury and mitogenic stimulation. Because of this etiologic heterogeneity, there is clear need for new therapeutic approaches to target each variant of this entity. Historical background, terminology, morphologic and phenotypic features, and suggested mechanisms are reviewed in this manuscript.

Original languageEnglish (US)
Pages (from-to)1276-1281
Number of pages6
JournalJournal of the American Society of Nephrology
Volume19
Issue number7
DOIs
StatePublished - Jul 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • Nephrology

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