Abstract
Radiocontrast administration is a common cause of hospital-acquired acute renal failure. It is associated with significant in-hospital and long-term morbidity and mortality and increases the costs of medical care by at least extending the hospital stay. A variety of therapeutic interventions, including saline hydration, diuretics, mannitol, calcium channel antagonists, theophylline, endothelin receptor antagonists, and dopamine, have been employed to prevent radiocontrast-induced acute renal failure. Recent advances have examined the impact of fenoldopam (dopamine-1 receptor agonist), N-acetylcysteine (antioxidant), iso-osmolar contrast agents, hemodialysis, and hemofiltration on ameliorating radiocontrast-induced acute renal failure. Although hydration with half-normal saline had remained the gold standard for the prevention of radiocontrast-induced nephropathy, recent data have revealed the superiority of hydration with normal saline over half-normal saline. This review focuses on the most recent studies of interventions to ameliorate radiocontrast-induced acute renal failure and provides a critical analysis of some of the recent studies conducted to prevent radiocontrast-induced nephropathy.
| Original language | English |
|---|---|
| Pages (from-to) | 127-132 |
| Number of pages | 6 |
| Journal | American Journal of Therapeutics |
| Volume | 12 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 1 2005 |
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Keywords
- Fenoldopam
- Iso-osmolar contrast medium
- N-acetylcysteine
- Radiocontrast-induced nephropathy
- Renal replacement therapy
ASJC Scopus subject areas
- Pharmacology
Cite this
Current trials of interventions to prevent radiocontrast-induced nephropathy. / Asif, Arif; Garces, Galo; Preston, Richard A; Roth, David.
In: American Journal of Therapeutics, Vol. 12, No. 2, 01.03.2005, p. 127-132.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Current trials of interventions to prevent radiocontrast-induced nephropathy
AU - Asif, Arif
AU - Garces, Galo
AU - Preston, Richard A
AU - Roth, David
PY - 2005/3/1
Y1 - 2005/3/1
N2 - Radiocontrast administration is a common cause of hospital-acquired acute renal failure. It is associated with significant in-hospital and long-term morbidity and mortality and increases the costs of medical care by at least extending the hospital stay. A variety of therapeutic interventions, including saline hydration, diuretics, mannitol, calcium channel antagonists, theophylline, endothelin receptor antagonists, and dopamine, have been employed to prevent radiocontrast-induced acute renal failure. Recent advances have examined the impact of fenoldopam (dopamine-1 receptor agonist), N-acetylcysteine (antioxidant), iso-osmolar contrast agents, hemodialysis, and hemofiltration on ameliorating radiocontrast-induced acute renal failure. Although hydration with half-normal saline had remained the gold standard for the prevention of radiocontrast-induced nephropathy, recent data have revealed the superiority of hydration with normal saline over half-normal saline. This review focuses on the most recent studies of interventions to ameliorate radiocontrast-induced acute renal failure and provides a critical analysis of some of the recent studies conducted to prevent radiocontrast-induced nephropathy.
AB - Radiocontrast administration is a common cause of hospital-acquired acute renal failure. It is associated with significant in-hospital and long-term morbidity and mortality and increases the costs of medical care by at least extending the hospital stay. A variety of therapeutic interventions, including saline hydration, diuretics, mannitol, calcium channel antagonists, theophylline, endothelin receptor antagonists, and dopamine, have been employed to prevent radiocontrast-induced acute renal failure. Recent advances have examined the impact of fenoldopam (dopamine-1 receptor agonist), N-acetylcysteine (antioxidant), iso-osmolar contrast agents, hemodialysis, and hemofiltration on ameliorating radiocontrast-induced acute renal failure. Although hydration with half-normal saline had remained the gold standard for the prevention of radiocontrast-induced nephropathy, recent data have revealed the superiority of hydration with normal saline over half-normal saline. This review focuses on the most recent studies of interventions to ameliorate radiocontrast-induced acute renal failure and provides a critical analysis of some of the recent studies conducted to prevent radiocontrast-induced nephropathy.
KW - Fenoldopam
KW - Iso-osmolar contrast medium
KW - N-acetylcysteine
KW - Radiocontrast-induced nephropathy
KW - Renal replacement therapy
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UR - http://www.scopus.com/inward/citedby.url?scp=17144383267&partnerID=8YFLogxK
U2 - 10.1097/01.mjt.0000143694.60662.11
DO - 10.1097/01.mjt.0000143694.60662.11
M3 - Article
VL - 12
SP - 127
EP - 132
JO - American Journal of Therapeutics
JF - American Journal of Therapeutics
SN - 1075-2765
IS - 2
ER -