Current treatment options for conjunctival and corneal intraepithelial neoplasia

Joann A. Giaconi, Carol Karp

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Intraepithelial neoplasia of the cornea and conjunctiva (CIN) and squamous cell carcinoma (SCC) lie on a continuum of the same dysplastic process. The etiology of this disease is most likely multifactorial, involving such factors as age, fair pigmentation, ultraviolet light exposure, human papillomavirus, and human immunodeficiency virus (HIV). It is known that CIN and SCC have a high recurrence rate after excision alone. Cryotherapy, radiation, and chemotherapeutics have been used after excision to reduce recurrence rates. More recently, mitomycin-C, 5-fluorouracil, and interferon-α-2b have been successfully employed alone against CIN and SCC, thereby eliminating the need for surgical excision altogether. The various treatments for CIN and SCC are reviewed and discussed.

Original languageEnglish
Pages (from-to)66-73
Number of pages8
JournalOcular Surface
Volume1
Issue number2
StatePublished - Apr 1 2003

Fingerprint

Squamous Cell Carcinoma
Neoplasms
Recurrence
Cryotherapy
Age Factors
Conjunctiva
Pigmentation
Mitomycin
Therapeutics
Ultraviolet Rays
Fluorouracil
Cornea
Interferons
HIV
Radiation

Keywords

  • 5-fluorouracil
  • Corneal intraepithelial neoplasia
  • Human immunodeficiency virus
  • Human papillomavirus
  • Interferon-α-2b
  • Mitomycin C.
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Current treatment options for conjunctival and corneal intraepithelial neoplasia. / Giaconi, Joann A.; Karp, Carol.

In: Ocular Surface, Vol. 1, No. 2, 01.04.2003, p. 66-73.

Research output: Contribution to journalArticle

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