Current Status of Pancreas Transplantation

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Transplantation of whole pancreas can restore euglycemia in patients with insulin-dependent, type 1 diabetes (T1D). It reverses diabetes in most patients, improving complications and quality of life, but requires chronic immunosuppression. Given the side effects and health risks associated with immunosuppression, exogenous insulin therapy remains the mainstay of treatment for most patients with T1D, unless patients cannot adequately control their metabolism with exogenous insulin or develop life-threatening complications (such as severe hypoglycemia and kidney failure) that can be corrected by transplantation. Pancreas transplantation (PT) is presently associated with excellent graft survival and function but requires surgery with the risk of perioperative mortality and morbidity. Thus, clinical indications and patient selection are very important. Patients with end-stage renal disease are candidates for simultaneous kidney-pancreas transplantation, which accounts for the majority of pancreas transplants. This chapter will review the current status of PT and discuss major challenges and future directions.

Original languageEnglish
Title of host publicationRegenerative Medicine Applications in Organ Transplantation
PublisherElsevier Inc.
Pages563-570
Number of pages8
ISBN (Print)9780123985231
DOIs
StatePublished - Jun 27 2014

Fingerprint

Pancreas Transplantation
Medical problems
Transplantation (surgical)
Insulin
Transplants
Type 1 Diabetes Mellitus
Health risks
Immunosuppression
Metabolism
Grafts
Surgery
Graft Survival
Hypoglycemia
Kidney Transplantation
Patient Selection
Chronic Kidney Failure
Renal Insufficiency
Pancreas
Transplantation
Quality of Life

Keywords

  • Autoimmunity
  • Immunosuppression
  • Pancreas transplantation
  • Rejection
  • Type 1 diabetes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ciancio, G., Sageshima, J., Chen, L. J., Pugliese, A., & Burke, G. W. (2014). Current Status of Pancreas Transplantation. In Regenerative Medicine Applications in Organ Transplantation (pp. 563-570). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-398523-1.00038-0

Current Status of Pancreas Transplantation. / Ciancio, Gaetano; Sageshima, Junichiro; Chen, Linda J; Pugliese, Alberto; Burke, George W.

Regenerative Medicine Applications in Organ Transplantation. Elsevier Inc., 2014. p. 563-570.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ciancio, G, Sageshima, J, Chen, LJ, Pugliese, A & Burke, GW 2014, Current Status of Pancreas Transplantation. in Regenerative Medicine Applications in Organ Transplantation. Elsevier Inc., pp. 563-570. https://doi.org/10.1016/B978-0-12-398523-1.00038-0
Ciancio G, Sageshima J, Chen LJ, Pugliese A, Burke GW. Current Status of Pancreas Transplantation. In Regenerative Medicine Applications in Organ Transplantation. Elsevier Inc. 2014. p. 563-570 https://doi.org/10.1016/B978-0-12-398523-1.00038-0
Ciancio, Gaetano ; Sageshima, Junichiro ; Chen, Linda J ; Pugliese, Alberto ; Burke, George W. / Current Status of Pancreas Transplantation. Regenerative Medicine Applications in Organ Transplantation. Elsevier Inc., 2014. pp. 563-570
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