Current status of neuroprotection trials for traumatic brain injury: Lessons from animal models and clinical studies

M. Ross Bullock, Bruce G. Lyeth, J. Paul Muizelaar

Research output: Contribution to journalReview article

142 Scopus citations

Abstract

LABORATORY STUDIES HAVE identified numerous potential therapeutic interventions that might have clinical application for the treatment of human traumatic brain injury. Many of these therapies have progressed into human clinical trials in severe traumatic brain injury. Numerous trials have been completed, and many others have been prematurely terminated or are currently in various phases of testing. The results of the completed Phase III trials have been generally disappointing, compared with the expectations produced by the successes of these interventions in animal laboratory studies. In this review, we summarize the current status of human traumatic brain injury clinical trials, as well as the animal laboratory studies that led to some of these trials. We summarize criteria for conducting clinical trials in severe traumatic brain injury, with suggestions for future improvements. We also attempt to identify factors that might contribute to the discrepancies between animal and human trials, and we propose recommendations that could help investigators avoid certain pitfalls in future clinical trials in traumatic brain injury.

Original languageEnglish (US)
Pages (from-to)207-220
Number of pages14
JournalNeurosurgery
Volume45
Issue number2
DOIs
StatePublished - Aug 1 1999

Keywords

  • Animal models
  • Clinical trials
  • Glasgow Outcome Scale
  • Neuroprotection
  • Therapy
  • Traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

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