Abstract
Despite substantial advances in islet isolation methods and immunosuppressive protocol, pancreatic islet cell transplantation remains an experimental procedure currently limited to the most severe cases of type 1 diabetes mellitus. The objectives of this treatment are to prevent severe hypoglycemic episodes in patients with hypoglycemia unawareness and to achieve a more physiological metabolic control. Insulin independence and long term-graft function with improvement of quality of life have been obtained in several international islet transplant centers. However, experimental trials of islet transplantation clearly highlighted several obstacles that remain to be overcome before the procedure could be proposed to a much larger patient population. This review provides a brief historical perspective of islet transplantation, islet isolation techniques, the transplant procedure, immunosuppressive therapy, and outlines current challenges and future directions in clinical islet transplantation.
| Original language | English |
|---|---|
| Pages (from-to) | 101-112 |
| Number of pages | 12 |
| Journal | Journal of Hepato-Biliary-Pancreatic Surgery |
| Volume | 16 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 2009 |
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Keywords
- Hypoglycemic
- Immuonsuppresive protocol
- Islet cell transplantation
- Pancreatic islet cells
ASJC Scopus subject areas
- Surgery
- Hepatology
Cite this
Current status of islet cell transplantation. / Ichii, Hirohito; Ricordi, Camillo.
In: Journal of Hepato-Biliary-Pancreatic Surgery, Vol. 16, No. 2, 01.01.2009, p. 101-112.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Current status of islet cell transplantation
AU - Ichii, Hirohito
AU - Ricordi, Camillo
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Despite substantial advances in islet isolation methods and immunosuppressive protocol, pancreatic islet cell transplantation remains an experimental procedure currently limited to the most severe cases of type 1 diabetes mellitus. The objectives of this treatment are to prevent severe hypoglycemic episodes in patients with hypoglycemia unawareness and to achieve a more physiological metabolic control. Insulin independence and long term-graft function with improvement of quality of life have been obtained in several international islet transplant centers. However, experimental trials of islet transplantation clearly highlighted several obstacles that remain to be overcome before the procedure could be proposed to a much larger patient population. This review provides a brief historical perspective of islet transplantation, islet isolation techniques, the transplant procedure, immunosuppressive therapy, and outlines current challenges and future directions in clinical islet transplantation.
AB - Despite substantial advances in islet isolation methods and immunosuppressive protocol, pancreatic islet cell transplantation remains an experimental procedure currently limited to the most severe cases of type 1 diabetes mellitus. The objectives of this treatment are to prevent severe hypoglycemic episodes in patients with hypoglycemia unawareness and to achieve a more physiological metabolic control. Insulin independence and long term-graft function with improvement of quality of life have been obtained in several international islet transplant centers. However, experimental trials of islet transplantation clearly highlighted several obstacles that remain to be overcome before the procedure could be proposed to a much larger patient population. This review provides a brief historical perspective of islet transplantation, islet isolation techniques, the transplant procedure, immunosuppressive therapy, and outlines current challenges and future directions in clinical islet transplantation.
KW - Hypoglycemic
KW - Immuonsuppresive protocol
KW - Islet cell transplantation
KW - Pancreatic islet cells
UR - http://www.scopus.com/inward/record.url?scp=63649092987&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=63649092987&partnerID=8YFLogxK
U2 - 10.1007/s00534-008-0021-2
DO - 10.1007/s00534-008-0021-2
M3 - Article
C2 - 19110649
AN - SCOPUS:63649092987
VL - 16
SP - 101
EP - 112
JO - Journal of Hepato-Biliary-Pancreatic Sciences
JF - Journal of Hepato-Biliary-Pancreatic Sciences
SN - 1868-6974
IS - 2
ER -