Current Status of Intestinal Transplantation

Gennaro Selvaggi, Andreas Tzakis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Intestinal transplantation is an ultimate surgical option for patients with irreversible failure of the digestive system. There are multiple types of intestinal grafts: isolated intestine, liver-intestine, multivisceral, and modified multivisceral. Indications for intestine transplant include lack of vascular access for parenteral nutrition, development of liver dysfunction, multiple episodes of sepsis or dehydration. Diagnoses which lead to intestinal transplant include gastroschisis and volvulus in the pediatric population, mesenteric thrombosis and trauma in the adult population. Pediatric recipients account for a majority of all intestinal transplants. Monitoring of the intestinal graft requires endoscopy with biopsy, since noninvasive markers for rejection are not yet significantly reliable. Major complications after surgery include rejection and infection episodes. Long-term patient survival in intestinal recipients is achievable with good quality of life and normal enteral function, however, overall rates of patient and graft survival are not as high as in other organ transplants.

Original languageEnglish
Title of host publicationRegenerative Medicine Applications in Organ Transplantation
PublisherElsevier Inc.
Pages481-492
Number of pages12
ISBN (Print)9780123985231
DOIs
StatePublished - Jun 27 2014

Fingerprint

Transplants
Transplantation
Grafts
Pediatrics
Liver
Intestines
Digestive system
Endoscopy
Biopsy
Nutrition
Dehydration
Surgery
Gastroschisis
Intestinal Volvulus
Digestive System
Parenteral Nutrition
Graft Survival
Population
Small Intestine
Blood Vessels

Keywords

  • Intestinal failure
  • Intestinal transplant
  • Multivisceral transplant
  • Rejection

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Selvaggi, G., & Tzakis, A. (2014). Current Status of Intestinal Transplantation. In Regenerative Medicine Applications in Organ Transplantation (pp. 481-492). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-398523-1.00032-X

Current Status of Intestinal Transplantation. / Selvaggi, Gennaro; Tzakis, Andreas.

Regenerative Medicine Applications in Organ Transplantation. Elsevier Inc., 2014. p. 481-492.

Research output: Chapter in Book/Report/Conference proceedingChapter

Selvaggi, G & Tzakis, A 2014, Current Status of Intestinal Transplantation. in Regenerative Medicine Applications in Organ Transplantation. Elsevier Inc., pp. 481-492. https://doi.org/10.1016/B978-0-12-398523-1.00032-X
Selvaggi G, Tzakis A. Current Status of Intestinal Transplantation. In Regenerative Medicine Applications in Organ Transplantation. Elsevier Inc. 2014. p. 481-492 https://doi.org/10.1016/B978-0-12-398523-1.00032-X
Selvaggi, Gennaro ; Tzakis, Andreas. / Current Status of Intestinal Transplantation. Regenerative Medicine Applications in Organ Transplantation. Elsevier Inc., 2014. pp. 481-492
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