Abstract
Intestinal transplantation is an ultimate surgical option for patients with irreversible failure of the digestive system. There are multiple types of intestinal grafts: isolated intestine, liver-intestine, multivisceral, and modified multivisceral. Indications for intestine transplant include lack of vascular access for parenteral nutrition, development of liver dysfunction, multiple episodes of sepsis or dehydration. Diagnoses which lead to intestinal transplant include gastroschisis and volvulus in the pediatric population, mesenteric thrombosis and trauma in the adult population. Pediatric recipients account for a majority of all intestinal transplants. Monitoring of the intestinal graft requires endoscopy with biopsy, since noninvasive markers for rejection are not yet significantly reliable. Major complications after surgery include rejection and infection episodes. Long-term patient survival in intestinal recipients is achievable with good quality of life and normal enteral function, however, overall rates of patient and graft survival are not as high as in other organ transplants.
| Original language | English |
|---|---|
| Title of host publication | Regenerative Medicine Applications in Organ Transplantation |
| Publisher | Elsevier Inc. |
| Pages | 481-492 |
| Number of pages | 12 |
| ISBN (Print) | 9780123985231 |
| DOIs | |
| State | Published - Jun 27 2014 |
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Keywords
- Intestinal failure
- Intestinal transplant
- Multivisceral transplant
- Rejection
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Current Status of Intestinal Transplantation. / Selvaggi, Gennaro; Tzakis, Andreas.
Regenerative Medicine Applications in Organ Transplantation. Elsevier Inc., 2014. p. 481-492.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Current Status of Intestinal Transplantation
AU - Selvaggi, Gennaro
AU - Tzakis, Andreas
PY - 2014/6/27
Y1 - 2014/6/27
N2 - Intestinal transplantation is an ultimate surgical option for patients with irreversible failure of the digestive system. There are multiple types of intestinal grafts: isolated intestine, liver-intestine, multivisceral, and modified multivisceral. Indications for intestine transplant include lack of vascular access for parenteral nutrition, development of liver dysfunction, multiple episodes of sepsis or dehydration. Diagnoses which lead to intestinal transplant include gastroschisis and volvulus in the pediatric population, mesenteric thrombosis and trauma in the adult population. Pediatric recipients account for a majority of all intestinal transplants. Monitoring of the intestinal graft requires endoscopy with biopsy, since noninvasive markers for rejection are not yet significantly reliable. Major complications after surgery include rejection and infection episodes. Long-term patient survival in intestinal recipients is achievable with good quality of life and normal enteral function, however, overall rates of patient and graft survival are not as high as in other organ transplants.
AB - Intestinal transplantation is an ultimate surgical option for patients with irreversible failure of the digestive system. There are multiple types of intestinal grafts: isolated intestine, liver-intestine, multivisceral, and modified multivisceral. Indications for intestine transplant include lack of vascular access for parenteral nutrition, development of liver dysfunction, multiple episodes of sepsis or dehydration. Diagnoses which lead to intestinal transplant include gastroschisis and volvulus in the pediatric population, mesenteric thrombosis and trauma in the adult population. Pediatric recipients account for a majority of all intestinal transplants. Monitoring of the intestinal graft requires endoscopy with biopsy, since noninvasive markers for rejection are not yet significantly reliable. Major complications after surgery include rejection and infection episodes. Long-term patient survival in intestinal recipients is achievable with good quality of life and normal enteral function, however, overall rates of patient and graft survival are not as high as in other organ transplants.
KW - Intestinal failure
KW - Intestinal transplant
KW - Multivisceral transplant
KW - Rejection
UR - http://www.scopus.com/inward/record.url?scp=84902934713&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84902934713&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-398523-1.00032-X
DO - 10.1016/B978-0-12-398523-1.00032-X
M3 - Chapter
AN - SCOPUS:84902934713
SN - 9780123985231
SP - 481
EP - 492
BT - Regenerative Medicine Applications in Organ Transplantation
PB - Elsevier Inc.
ER -