Current paradigms in covid-19 research: Proposed treatment strategies, recent trends and future directions

Anil K. Sharma, Varruchi Sharma, Arun Sharma, Suresh Pallikkuth, Anil Kumar Sharma

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: Recent pandemic of coronavirus disease caused by a novel coronavi-rus SARS-CoV-2 in humans is the third outbreak by this family of viruses leading to an acute respiratory infection, which has been a major cause of morbidity and mortality worldwide.The virus belongs to the genus, Betacoronavirus, which has been recently reported to have significant similarity (>89%) to a severe acute respiratory syndrome (SARS)-related member of the Sarbecoviruses. Current researches are not sufficient to understand the etiological and immunopathobiological parameters related to COVID-19 so as to have a therapeutic solution to the problem. Methods: A structured search of bibliographic databases for peer-reviewed research literature has been carried out using focused review questions and inclusion/exclusion criteria. Further Standard tools were implied in order to appraise the quality of retrieved papers. The character-istic outcomes of screened research and review articles along with analysis of the interventions and findings of included studies using a conceptual framework have been described em-ploying a deductive qualitative content analysis methodology. Results: This review systematically summarizes the immune-pathobiological characteristics, diagnosis, potential therapeutic options for the treatment and prevention of COVID-19 based on the current published literature and evidence. The current review has covered 125 peer-reviewed articles, the majority of which are from high-income technically developed coun-tries providing the most recent updates about the current understanding of the COVID-19 bringing all the significant findings and related researches together at a single platform. In ad-dition, possible therapeutic interventions, treatment strategies and vaccine development initia-tives to manage COVID-19 have been proposed. Conclusion: It is anticipated that this review would certainly assist the public in general and scientific community in particular to recognize and effectively deal with COVID-19, providing a reference guide for futuristic studies.

Original languageEnglish (US)
Pages (from-to)3173-3192
Number of pages20
JournalCurrent medicinal chemistry
Volume28
Issue number16
DOIs
StatePublished - 2021
Externally publishedYes

Keywords

  • Coronavirus
  • Pandemic
  • Pathogenesis
  • SARS-CoV-2
  • Therapeutic
  • Treatment
  • Vaccines

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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